PMID: 8955902Jan 1, 1996Paper

RNAs mediating cotranslational insertion of selenocysteine in eukaryotic selenoproteins

Biochimie
N HubertA Krol

Abstract

Selenocysteine, a selenium-containing analog of cysteine, is found in the prokaryotic and eukaryotic kingdoms in active sites of enzymes involved in oxidation-reduction reactions. Its biosynthesis and cotranslational insertion into selenoproteins is performed by an outstanding mechanism, implying the participation of several gene products. The tRNA(Sec) is one of these. In eukaryotes, its transcription mode by RNA polymerase III differs from that of classical tRNA genes, both at the level of the promoter elements and transcription factors involved. In addition, enhanced transcription is afforded by a newly characterized zinc finger activator. Not only transcription of the gene, but also the tRNA(Sec) itself is atypical since its 2D and 3D structures exhibit features which set it apart from classical tRNAs. Decoding of eukaryotic selenocysteine UGA codons requires a stem-loop structure in the 3'UTR of mRNAs, the selenocysteine insertion sequence (SECIS) element. Structure probing and sequence comparisons led us to propose a 2D structure model for the SECIS element, containing a novel RNA motif composed of four consecutive non-Watson-Crick base-pairs. A 3D model, rationalizing the accessibility data, was elaborated by computer mo...Continue Reading

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Citations

Jul 25, 2000·Nucleic Acids Research·D FagegaltierA Krol
Jun 15, 2007·Genome Research·Stefan WashietlPeter F Stadler
May 22, 2007·RNA·Paul Piccinelli, Tore Samuelsson
Jan 6, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Bor-Rung OuJan-Ying Yeh
Mar 9, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·S G Patching, P H Gardiner
Nov 18, 2005·Insect Biochemistry and Molecular Biology·Raquel Cossío-BayúgarPatricia J Holman
Mar 6, 2007·The Journal of Biological Chemistry·Sergey V NovoselovVadim N Gladyshev
Aug 1, 2013·Biomolecular Concepts·Jonathan N Gonzalez-FloresPaul R Copeland
Sep 13, 2018·International Journal of Molecular Sciences·Mikko J Lammi, Chengjuan Qu

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