RNAs with dual specificity and dual RNAs with similar specificity

Science
G J Connell, M Yarus

Abstract

The biological role of RNA is delimited by its possible reactions, which can be explored by selection. A comparison of selected RNAs that bind one ligand with those that bind two related ligands suggests that a single nucleotide substitution can expand binding specificity. An RNA site with dual (joint) specificity has adenine and cytosine bases whose pKa's appear shifted upward, thereby mimicking an efficient general acid-base catalyst. The joint site also contains two conserved, looped arginine-coding triplets implicated in arginine site formation. Two selected joint RNAs are identical in some regions and distinct in others. The distinct regions, like some peptides, seem to function similarly without being similar in primary structure.

References

May 24, 1991·Science·B J CalnanA D Frankel
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S M FreierD H Turner
Jan 1, 1989·Methods in Enzymology·J F Milligan, O C Uhlenbeck
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T H Kao, D M Crothers
May 1, 1994·Nature Structural Biology·I Majerfeld, M Yarus
Aug 5, 1993·Nature·M Sassanfar, J W Szostak
Jun 1, 1993·Biochemistry·G J ConnellM Yarus

❮ Previous
Next ❯

Citations

Dec 1, 1993·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·G J Connell, E L Christian
Jul 7, 2005·Journal of Molecular Evolution·Irene MajerfeldMichael Yarus
Dec 12, 2001·Trends in Biochemical Sciences·J M Murray, J A Doudna
Sep 30, 1998·Chemistry & Biology·R D Knight, L F Landweber
Jan 23, 1999·Current Opinion in Chemical Biology·D Sen, C R Geyer
Apr 29, 2000·RNA·R D Knight, L F Landweber
Apr 29, 2000·RNA·A D EllingtonC A Shaw
May 10, 2001·RNA·E A Curtis, D P Bartel
Aug 1, 1996·Nature Biotechnology·D W DroletT S Romig
May 5, 2005·Nature Structural & Molecular Biology·Jennifer A Doudna, Jon R Lorsch
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A PeracchiD Herschlag
Aug 25, 1995·Nucleic Acids Research·J BinkleyL Gold
Sep 28, 2005·Nucleic Acids Research·Irene Majerfeld, Michael Yarus
Oct 4, 2005·Nucleic Acids Research·Kelly A PlummerGregory L Verdine
Jul 23, 1999·Annals of the New York Academy of Sciences·R D Knight, L F Landweber
Feb 3, 1995·Science·M IllangasekareM Yarus
Jan 1, 1997·Annual Review of Biochemistry·G J Narlikar, D Herschlag
Jun 29, 2000·Annual Review of Biochemistry·D S Wilson, J W Szostak
Jun 5, 2002·Annual Review of Biochemistry·I-hung Shih, Michael D Been
Jun 15, 2005·Annual Review of Biochemistry·Michael YarusRob Knight
Mar 3, 2010·RNA·Teresa JanasMichael Yarus
Jun 18, 2003·RNA·Saba Valadkhan, James L Manley
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jonas NoeskeJens Wöhnert
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·M Duane Smith, Richard A Collins
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Illangasekare, M Yarus
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·G F Joyce
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·T L SheppardG F Joyce
Mar 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shelley D CopleyHarold J Morowitz
Jan 25, 2012·Chembiochem : a European Journal of Chemical Biology·Yuanfeng PangNorio Teramae
Nov 24, 2004·Current Opinion in Chemical Biology·Randall A HughesMatthew Levy
May 24, 2005·Journal of Molecular Biology·Yaroslav I KuzminMartha J Fedor
Jun 11, 1999·Current Opinion in Structural Biology·M Famulok
May 16, 2014·RNA Biology·Edward A Curtis, David R Liu
Apr 23, 2013·Chemistry & Biology·Edward A Curtis, David R Liu
Sep 1, 1995·Current Biology : CB·I Hirao, A D Ellington
Jul 12, 2011·Biochimie·Giulia TaliniEnzo Gallori
Oct 18, 2000·Chemistry & Biology·M Yarus, M Welch
Dec 12, 2012·The Journal of Physical Chemistry. B·Maria Schill, Thorsten Koslowski
Mar 19, 2005·Social Work in Health Care·Kathryn Basham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.