PMID: 9525594Apr 3, 1998Paper

RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection

Journal of Virology
X L LiB A Hassel

Abstract

The 2',5'-oligoadenylate (2-5A) system is an RNA degradation pathway which plays an important role in the antipicornavirus effects of interferon (IFN). RNase L, the terminal component of the 2-5A system, is thought to mediate this antiviral activity through the degradation of viral RNA; however, the capacity of RNase L to selectively target viral RNA has not been carefully examined in intact cells. Therefore, the mechanism of RNase L-mediated antiviral activity was investigated following encephalomyocarditis virus (EMCV) infection of cell lines in which expression of transfected RNase L was induced or endogenous RNase L activity was inhibited. RNase L induction markedly enhanced the anti-EMCV activity of IFN via a reduction in EMCV RNA. Inhibition of endogenous RNase L activity inhibited this reduction in viral RNA. RNase L had no effect on IFN-mediated protection from vesicular stomatitis virus. RNase L induction reduced the rate of EMCV RNA synthesis, suggesting that RNase L may target viral RNAs involved in replication early in the virus life cycle. The RNase L-mediated reduction in viral RNA occurred in the absence of detectable effects on specific cellular mRNAs and without any global alteration in the cellular RNA profile...Continue Reading

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T W Nilsen, C Baglioni
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Aug 15, 1991·European Journal of Biochemistry·B R Williams
Nov 6, 1986·Journal of Immunological Methods·H TadaK Tsukamoto
Dec 1, 1985·Medical Hypotheses·W M Clouston, J F Kerr
Oct 1, 1984·Journal of Virology·B AlarconL Carrasco
Jan 29, 1982·Biochemical and Biophysical Research Communications·P J CayleyI M Kerr
May 1, 1982·European Journal of Biochemistry·R H SilvermanI M Kerr
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K B MarcuC M Croce
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G MerlinM Revel
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·M Collins
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Feb 24, 1995·The Journal of Biological Chemistry·B Dong, R H Silverman
Apr 1, 1995·Molecular and Cellular Biology·G HougeS O Døskeland
Jan 1, 1996·Cancer Investigation·D V Kalvakolanu, E C Borden
Mar 1, 1997·Journal of Virology·K V KiblerB L Jacobs
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·S D DerB R Williams
Sep 18, 1997·The Journal of Experimental Medicine·J C CastelliR J Youle
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

❮ Previous
Next ❯

Citations

Feb 28, 2006·Journal of Virology·Svetlana V ScherbikMargo A Brinton
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ren-Jye LinYi-Ling Lin
Feb 3, 2015·The Journal of Clinical Investigation·Kylie M QuinnRobert A Seder
Sep 29, 2015·Virology Journal·Helen K Palma-OcampoGerardo Santos-López
Aug 9, 2020·European Journal of Immunology·Xiangle ZhangHaixue Zheng
Feb 28, 2002·Journal of Virology·Luca G GuidottiFrancis V Chisari
Aug 5, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·F Le RoyC Bisbal
Sep 9, 2004·Microbiology and Molecular Biology Reviews : MMBR·Qiaoqiao Wang, Gordon G Carmichael
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Nov 9, 2005·Microscopy Research and Technique·Srikanta DashRobert Garry
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Srikanta DashSwan N Thung
Oct 31, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Barbara I ChaseAimin Zhou
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tao LanSudhir Agrawal
Jun 7, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Maoxiang Li, James J Pestka
Sep 28, 2006·IUBMB Life·Shu-Ling LiangAimin Zhou
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Xiao-Ling LiBret A Hassel
Dec 11, 2013·PloS One·Xin YiAimin Zhou
May 14, 2016·Wiley Interdisciplinary Reviews. RNA·Eric Roberto Guimarães Rocha AguiarJoão Trindade Marques
May 24, 2005·Nature Structural & Molecular Biology·Florence Le RoyStuart W Peltz
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Ling LiBret A Hassel
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Krishnamurthy MalathiRobert H Silverman
Apr 5, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah E Brennan-LaunBret A Hassel
Jun 14, 2012·Scandinavian Journal of Immunology·C BrennerJ Turner
Jan 14, 2016·International Journal of Molecular Sciences·Heather J EzelleBret A Hassel
Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Díaz-GuerraM Esteban
Jan 13, 2006·Nature Chemical Biology·Hiroshi SakamotoMasayuki Sudoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.