RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Journal of Neuroinflammation
Antonio VallarolaC Bendotti

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuromuscular system leading to complete paralysis and premature death. The multifactorial nature of ALS that involves both cell-autonomous and non-cell-autonomous processes contributes to the lack of effective therapies, usually targeted to a single pathogenic mechanism. RNS60, an experimental drug containing oxygenated nanobubbles generated by modified Taylor-Couette-Poiseuille flow with elevated oxygen pressure, has shown anti-inflammatory and neuroprotective properties in different experimental paradigms. Since RNS60 interferes with multiple cellular mechanisms known to be involved in ALS pathology, we evaluated its effect in in vitro and in vivo models of ALS. Co-cultures of primary microglia/spinal neurons exposed to LPS and astrocytes/spinal neurons from SOD1G93A mice were used to examine the effect of RNS60 or normal saline (NS) on the selective motor neuron degeneration. Transgenic SOD1G93A mice were treated with RNS60 or NS (300 μl/mouse intraperitoneally every other day) starting at the disease onset and examined for disease progression as well as pathological and biochemical alterations. RNS60 protected motor neuron...Continue Reading

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Citations

Nov 21, 2018·Muscle & Nerve·Sabrina PaganoniNazem Atassi
Dec 4, 2019·Journal of Cellular Physiology·Misagh RajabinejadAlireza Rezaiemanesh
Nov 2, 2018·Current Medicinal Chemistry·Kyoung Sang ChoGyun Jee Song
Jun 3, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·I GiovannelliJ Kirby
May 28, 2020·Expert Opinion on Emerging Drugs·Andrea BarpChristian Lunetta
Aug 5, 2020·Expert Opinion on Therapeutic Targets·Yiran Wang, Rickie Patani
Jan 11, 2019·Disease Models & Mechanisms·Francesca De GiorgioAbraham Acevedo-Arozena
Apr 26, 2019·Journal of Cachexia, Sarcopenia and Muscle·Savina ApolloniCinzia Volonté
Oct 2, 2019·Neural Regeneration Research·Alessandra PisciottaGianluca Carnevale
Feb 23, 2020·Neurobiology of Disease·Silvia LuottiValentina Bonetto
Feb 18, 2020·Neuropharmacology·Adriano ChiòGabriele Mora
Apr 4, 2021·International Journal of Molecular Sciences·Elisabeth TraiffortAmina Zahaf
Jun 22, 2021·Neuroscience and Biobehavioral Reviews·Fabiola De MarchiLetizia Mazzini

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Methods Mentioned

BETA
transgenic
confocal microscopy
PCR
dot-blot

Software Mentioned

ImageJ
NeuronJ
Image J
Fiji
Progenesis PG240
Quantity One

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