RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development

Developmental Biology
Yon Ju JiJoohong Ahnn

Abstract

The rnt-1 gene is the only Caenorhabditis elegans homologue of the mammalian RUNX genes. Several lines of molecular biological evidence have demonstrated that the RUNX proteins interact and cooperate with Smads, which are transforming growth factor-beta (TGF-beta) signal mediators. However, the involvement of RUNX in TGF-beta signaling has not yet been supported by any genetic evidence. The Sma/Mab TGF-beta signaling pathway in C. elegans is known to regulate body length and male tail development. The rnt-1(ok351) mutants show the characteristic phenotypes observed in mutants of the Sma/Mab pathway, namely, they have a small body size and ray defects. Moreover, RNT-1 can physically interact with SMA-4 which is one of the Smads in C. elegans, and double mutant animals containing both the rnt-1(ok351) mutation and a mutation in a known Sma/Mab pathway gene displayed synergism in the aberrant phenotypes. In addition, lon-1(e185) mutants was epistatic to rnt-1(ok351) mutants in terms of long phenotype, suggesting that lon-1 is indeed downstream target of rnt-1. Our data reveal that RNT-1 functionally cooperates with the SMA-4 proteins to regulate body size and male tail development in C. elegans.

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Citations

Aug 4, 2006·BMC Developmental Biology·Catarina Mörck, Marc Pilon
Dec 27, 2007·Biochemical and Biophysical Research Communications·Jiwon Shim, Junho Lee
Mar 31, 2009·Journal of Cellular Biochemistry·James A Coffman
Jul 25, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masashi MaekawaHiroyuki Arai
Nov 23, 2006·Biochemical and Biophysical Research Communications·Gunasekaran SingaraveluJoohong Ahnn
Nov 23, 2013·Experimental Cell Research·Simon Tuck
Feb 1, 2007·Journal of Cellular Biochemistry·Hiroshi KagoshimaYuji Kohara
Jul 1, 2005·Journal of Cellular Biochemistry·Yon Ju JiJoohong Ahnn
Jan 17, 2015·Nature Reviews. Cancer·Yoshiaki ItoLinda Shyue Huey Chuang

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