PMID: 6405362Mar 1, 1983Paper

Ro 15-1788 is a potent antagonist of benzodiazepines in the olfactory cortex slice

Pflügers Archiv : European journal of physiology
C N Scholfield

Abstract

The olfactory cortex slice from the guinea pig has been used to test the benzodiazepine antagonist, Ro 15-1788. Bath application of muscimol has a GABA-mimetic effect on the resting input conductance of these neurones. Benzodiazepines increase the potency of muscimol and increase the duration of postsynaptic inhibitory conductance. To measure the effect of muscimol, the input conductance was measured either directly using intracellular microelectrodes or by measuring its effect on the amplitude of the evoked compound potentials recorded from the slice surface after stimulating the lateral olfactory tract. The potentiation of postsynaptic inhibition produced by benzodiazepines was measured indirectly by their effect on the amplitude of the second of two evoked compound potentials. All of the potentiating effects of diazepam, clonazepam, flurazepam and chlordiazepoxide were blocked by Ro 15-1788 (0.01-10 mumol/l). Ro 15-1788 up to a concentration of 10 mumol/l had no effect on any of the synaptic or electrical responses when applied alone. General anaesthetics which also potentiate inhibition were unaffected by Ro 15-1788. It is concluded that Ro 15-1788 is a highly potent and specific benzodiazepine antagonist in this preparation.

References

Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·H Möhler, T Okada
Feb 1, 1978·The Journal of Physiology·C N Scholfield
Feb 1, 1978·The Journal of Physiology·C N Scholfield
Aug 16, 1974·Brain Research·J A HarveyD A Brown
Nov 1, 1968·European Journal of Pharmacology·F MarcucciS Garattini
Jan 18, 1980·Science·J F TallmanD W Gallager
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H MöhlerJ G Richards
Apr 9, 1981·Nature·W HunkelerW Haefely
Jul 1, 1981·Journal of Neurochemistry·R W Olsen
Jun 1, 1983·Pflügers Archiv : European journal of physiology·M Riley, C N Scholfield
Feb 1, 1980·Pflügers Archiv : European journal of physiology·C N Scholfield
Oct 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·C N Scholfield

❮ Previous
Next ❯

Citations

Jan 1, 1986·Pflügers Archiv : European journal of physiology·G Sanderson, C N Scholfield
Dec 1, 1986·Electroencephalography and Clinical Neurophysiology·R Velluti, M Pedemonte
Dec 10, 1984·Brain Research·N L Harrison, M A Simmonds

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.