Roads to the development of improved pertussis vaccines paved by immunology

Pathogens and Disease
Jolanda BrummelmanKingston H G Mills

Abstract

Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protective immune responses when compared with immunization with acellular pertussis vaccines. Therefore, the immune responses induced with whole cell vaccine or after infection can be used as a benchmark for the development of third-generation vaccines against pertussis. Here, we review the literature on the immunology of B. pertussis infection and vaccination and discuss the lessons learned that will help in the design of improved pertussis vaccines.

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Citations

Jun 22, 2017·Proceedings of the National Academy of Sciences of the United States of America·Carlin AloeBarry R Bloom
Mar 16, 2017·Cold Spring Harbor Perspectives in Biology·Christiane S Eberhardt, Claire-Anne Siegrist
Mar 16, 2017·Cold Spring Harbor Perspectives in Biology·Nicolas BurdinStanley A Plotkin
Sep 23, 2016·Clinical and Vaccine Immunology : CVI·Nicholas H CarbonettiMaria E Rodriguez
Sep 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tod J Merkel
Jun 30, 2019·Toxins·Karen ScanlonNicholas Carbonetti
Feb 26, 2016·Current Opinion in Infectious Diseases·Nicholas H Carbonetti
May 10, 2018·Emerging Microbes & Infections·Charlotte BrookesAndrew Gorringe
May 31, 2018·PloS One·Sietske KooijmanHugo D Meiring
Jan 11, 2020·Frontiers in Immunology·Monica C GestalEric T Harvill
Oct 5, 2021·Frontiers in Immunology·Francisco CarriquiribordeDaniela F Hozbor

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