Robot-guided neuronavigated rTMS as an alternative therapy for central (neuropathic) pain: Clinical experience and long-term follow-up

European Journal of Pain : EJP
B PommierR Peyron

Abstract

Repetitive transcranial magnetic stimulation (rTMS) appears as a useful tool to alleviate neuropathic pain but only few data are available for the long-term benefit of this treatment. Here we report the effects of rTMS sessions, considered as a possible therapy for pain relief after a failure of different medications in patients with central (neuropathic) pain. We review here the prospectively collected data of the first forty patients treated as follow: 20 Hz stimulation delivered over the contralateral primary motor cortex (M1), each 3-4 weeks. A total of 440 rTMS sessions was collected (mean sessions number: 11, range: 1-37, follow-up 312 days on average, maximum 2.8 years). After four sessions, nine patients (22.5%) discontinued rTMS because of a lack of efficiency (<10% pain-relief). The other 31 patients (77.5%) had a cumulative effect across sessions leading to a mean pain relief of 41% for a duration of 15.6 days. A correlation was observed between pain relief in the first session and long-term pain relief (R = 0.649. p = 5.6*10(-6) ). Both intensity and duration of pain relief were significantly better for patients with persistent laser evoked potentials (LEPs, p = 0.049 and 0.0018). We did not observe any adverse-effe...Continue Reading

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Citations

May 18, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Turo NurmikkoPaul Sacco
Mar 27, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Albert LeungUNKNOWN and the Expert Consensus Panel
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May 8, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Luis Garcia-LarreaNathalie André-Obadia
Oct 23, 2019·Journal of Neural Transmission·X MoissetD Fontaine
Jan 22, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Nobuhiko MoriYouichi Saitoh
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Nov 28, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiUNKNOWN basis of this article began with a Consensus Statement from the IFCN Workshop on "Present, Future of TMS: Safety, Ethical Gu
May 22, 2020·Neurophysiologie clinique = Clinical neurophysiology·Benjamin PommierFrançois Vassal
May 11, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hasan HodajJean-Pascal Lefaucheur

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