Robust activation detection methods for real-time and offline fMRI analysis

Computer Methods and Programs in Biomedicine
Kaya OguzAli Saffet Gonul

Abstract

We propose two contributions with novel approaches to fMRI activation analysis. The first is to apply confidence intervals to locate activations in real-time, and second is a new metric based on robust regression of fMRI signals. These contributions are implemented in our four proposed methods; Instantaneous Activation Method (IAM), Instantaneous Activation Method with Past Blocks (IAMP) for real-time analysis, Task Robust Regression Distance Method (TRRD) for the new metric with robust regression and Instantaneous Robust Regression Distance Method (IRRD) for both contributions. For comparison, a statistical offline method called Task Activation Method (TAM) and a correlation analysis method are also implemented. The methods are initially evaluated with synthetic data generated using two different approaches; first using varying hemodynamic response function signals to simulate a wide range of stimuli responses, along with a Gaussian white noise, and second using no activity state data of a real fMRI experiment, which removes the need to generate noise. The methods are also tested with real fMRI experiments and compared with the results obtained by the widely used SPM tool. The results show that instantaneous methods reveal act...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Bapun K GiriKoel Das
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EunSang BakJohn P Brockway
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
O FrimanH Knutsson
Medical Image Computing and Computer-assisted Intervention : MICCAI
Guillermo A CecchiA Ravishankar Rao
Information Processing in Medical Imaging : Proceedings of the ... Conference
Wanmei Ou, Polina Golland
© 2022 Meta ULC. All rights reserved