PMID: 33219247DOI: 10.1038/s41598-020-77162-3Nov 22, 2020Paper
Robust alternative to the righting reflex to assess arousal in rodents.
Scientific Reports
Sijia Gao, Diany Paola Calderon
Abstract
The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.
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Citations
Dec 6, 2020·Current Opinion in Neurology·Diany P Calderon, Nicholas D Schiff
Mar 12, 2021·Frontiers in Behavioral Neuroscience·Elena MinakovaSusan E Maloney
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