Robust Cell Detection of Histopathological Brain Tumor Images Using Sparse Reconstruction and Adaptive Dictionary Selection

IEEE Transactions on Medical Imaging
Hai SuLin Yang

Abstract

Successful diagnostic and prognostic stratification, treatment outcome prediction, and therapy planning depend on reproducible and accurate pathology analysis. Computer aided diagnosis (CAD) is a useful tool to help doctors make better decisions in cancer diagnosis and treatment. Accurate cell detection is often an essential prerequisite for subsequent cellular analysis. The major challenge of robust brain tumor nuclei/cell detection is to handle significant variations in cell appearance and to split touching cells. In this paper, we present an automatic cell detection framework using sparse reconstruction and adaptive dictionary learning. The main contributions of our method are: 1) A sparse reconstruction based approach to split touching cells; 2) An adaptive dictionary learning method used to handle cell appearance variations. The proposed method has been extensively tested on a data set with more than 2000 cells extracted from 32 whole slide scanned images. The automatic cell detection results are compared with the manually annotated ground truth and other state-of-the-art cell detection algorithms. The proposed method achieves the best cell detection accuracy with a F1 score = 0.96.

References

Apr 16, 2004·IEEE Transactions on Medical Imaging·V GrauS K Warfield
Sep 21, 2004·IEEE Transactions on Pattern Analysis and Machine Intelligence·Vladimir Kolmogorov, Ramin Zabih
Jun 10, 2006·IEEE Transactions on Bio-medical Engineering·K Z MaoPuay-Hoon Tan
Feb 3, 2007·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Hiroyuki TakedaPeyman Milanfar
Mar 16, 2007·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Bahram ParvinMary Helen Barcellos-Hoff
Jul 27, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Gang LinBadrinath Roysam
Feb 14, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·P YanS T C Wong
Nov 6, 2008·Histopathology·D ScheieK Beiske
Dec 27, 2008·IEEE Transactions on Pattern Analysis and Machine Intelligence·John WrightYi Ma
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Jierong Cheng, Jagath C Rajapakse
Nov 4, 2009·IEEE Transactions on Bio-medical Engineering·Yousef Al-KofahiBadrinath Roysam
Jul 17, 2010·IEEE Transactions on Pattern Analysis and Machine Intelligence·Hae Jong Seo, Peyman Milanfar
Jul 27, 2010·IEEE Transactions on Bio-medical Engineering·Chanho Jung, Changick Kim
Apr 14, 2011·IEEE Transactions on Medical Imaging·Hui KongKamel Belkacem-Boussaid
Dec 14, 2011·The New England Journal of Medicine·Claudia F LucchinettiRichard M Ransohoff
Jan 1, 2011·Journal of Pathology Informatics·Andreas KårsnäsRasmus Larsen
Aug 1, 2012·IEEE Transactions on Pattern Analysis and Machine Intelligence·Chiwoo Park Yu Ding
Nov 20, 2012·Annual Review of Pathology·Farzad GhaznaviMichael Feldman
Dec 12, 2012·IEEE Transactions on Medical Imaging·Hang ChangBahram Parvin
Jan 25, 2014·IEEE Transactions on Pattern Analysis and Machine Intelligence·Yongzhen HuangTieniu Tan
Apr 25, 2014·IEEE Transactions on Bio-medical Engineering·Mitko VetaMax A Viergever
Jul 1, 2014·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Hai SuLin Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomedizinische Technik. Biomedical Engineering
Saif Dawood Salman Al-ShaikhliBodo Rosenhahn
IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society
Shu Liao, Dinggang Shen
Medical Image Computing and Computer-assisted Intervention : MICCAI
Shu LiaoDinggang Shen
© 2021 Meta ULC. All rights reserved