Robust cerebrovascular blood velocity and flow rate estimation from 4D-CTA

Medical Physics
Pierre BouillotVitor M Pereira

Abstract

Blood velocity and flow rate information may be helpful for a wide variety of applications, but it often requires separate acquisitions. The dynamic information combined with the high spatial resolution of four-dimensional computed tomography angiography (4D-CTA) offers the possibility to quantify blood flow simultaneous to vascular anatomy. A 4D-CTA clinical protocol with a novel dedicated postprocessing were validated in vitro in a patient-specific model, and tested in a pilot study of six patients. Blood flow was assessed in both internal carotid (ICAs) and vertebral (VAs) arteries by analyzing spatial displacement of contrast agent in the form of time-intensity curves (TICs). Unlike previous approaches, it does not require any a priori assumptions about TIC shape, but rather computes mean velocity and flow rates from the spatial displacement of the TICs along the automatically segmented vessels. In vitro experiments showed good agreement between 4D-CTA and flowmeter measurements under steady and pulsatile flow conditions. In vivo measurements exhibited large interpatient variability of the TIC shapes, from which blood flow rates could nevertheless be successfully measured in all patients and investigated vessels. On average...Continue Reading

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Citations

Nov 28, 2019·Journal of Neurointerventional Surgery·Nicole M CancelliereDavid A Steinman
Jan 24, 2021·Journal of Biomechanics·Trung Bao Le
Oct 8, 2021·Biomedical Physics & Engineering Express·S HuangB Sixou

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