PMID: 9530835Apr 8, 1998Paper

Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants

Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology
C Helfrich-Förster

Abstract

Mutations at the disconnected (disco) locus of Drosophila melanogaster disrupt neural cell patterning in the visual system, leading to the loss of many optic lobe neurons. Drosophila's presumptive circadian pacemaker neurons--the dorsal and ventral lateral neurons--are usually among the missing cells, and most disco flies are behaviorally arrhythmic. In this study, I show that ventral lateral neurons (LNvs) are occasionally present and provoke robust circadian rhythmicity in disco mutants. Of 357 individual disco flies four animals with robust circadian rhythmicity were found. All four retained LNvs together with terminals in the superior protocerebrum. Residual or bi-circadian rhythmicity was found in about 20% of all flies; the remaining flies were completely arrhythmic. One of the flies with residual rhythmicity and two of the arrhythmic flies also had some LNvs stained. However, these flies lacked the LNv fibers in the superior protocerebrum. The results suggest that the presence of single LNvs is sufficient to provoke robust circadian rhythmicity in locomotor activity if the LNv terminals reach the superior protocerebrum. The presence of residual or bi-circadian rhythmicity in 20% of the flies without LNvs indicates that a...Continue Reading

Citations

Jan 18, 2007·Pflügers Archiv : European journal of physiology·Ben Collins, Justin Blau
Sep 6, 2001·Neuroscience Research·T J NakamuraF Kimura
Oct 15, 2003·Behavioural Processes·Bruno van Swinderen, Rozi Andretic
Oct 15, 2003·Behavioural Processes·André KlarsfeldFrançois Rouyer
Apr 5, 2007·Nature Protocols·Ezio Rosato, Charalambos P Kyriacou
May 25, 2006·European Journal of Human Genetics : EJHG·Ezio RosatoCharalambos P Kyriacou
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuhua ShangMichael Rosbash
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Sakai, N Ishida
Nov 17, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H G McWattersD Staiger
Nov 17, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G Foster, C Helfrich-Förster
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·J C HallE Dolezelova
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·C Helfrich-FörsterF Rouyer
Feb 22, 2005·Genes, Brain, and Behavior·C Helfrich-Förster
Apr 13, 2000·Annual Review of Entomology·J M Giebultowicz
Feb 22, 2001·Annual Review of Physiology·J A Williams, A Sehgal
Sep 17, 2003·PLoS Biology·Ying PengMichael Rosbash
May 1, 2009·PLoS Biology·Johannes LandskronRalf Stanewsky
Apr 10, 2009·PLoS Biology·Taishi YoshiiCharlotte Helfrich-Förster
Dec 18, 2013·PLoS Biology·Esteban J BeckwithMaría Fernanda Ceriani
Apr 23, 2009·PloS One·Valerie L KilmanRavi Allada
Apr 6, 2012·PloS One·Luis Diambra, Coraci P Malta
Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·E Axel Gorostiza, M Fernanda Ceriani
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vasu SheebaTodd C Holmes
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juliana BenitoPaul E Hardin
Jul 16, 2008·Zoological Science·Tatsumori SekineMasami Shimoda
Dec 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ben H CollinsCharalambos P Kyriacou
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Andretic, J Hirsh
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang BachleitnerCharlotte Helfrich-Förster
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·María de la Paz FernándezMaría Fernanda Ceriani
Jan 17, 2009·Journal of Genetics·Vasu Sheeba
Dec 26, 2009·Cellular and Molecular Life Sciences : CMLS·Kenji Tomioka, Akira Matsumoto
Mar 3, 2011·Cellular and Molecular Life Sciences : CMLS·Johannes StraussHeinrich Dircksen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.