Robust Empirical Bayesian Reconstruction of Distributed Sources for Electromagnetic Brain Imaging.

IEEE Transactions on Medical Imaging
Chang CaiSrikantan S Nagarajan

Abstract

Electromagnetic brain imaging is the reconstruction of brain activity from non-invasive recordings of the magnetic fields and electric potentials. An enduring challenge in this imaging modality is estimating the number, location, and time course of sources, especially for the reconstruction of distributed brain sources with complex spatial extent. Here, we introduce a novel robust empirical Bayesian algorithm that enables better reconstruction of distributed brain source activity with two key ideas: kernel smoothing and hyperparameter tiling. Since the proposed algorithm builds upon many of the performance features of the sparse source reconstruction algorithm - Champagne and we refer to this algorithm as Smooth Champagne. Smooth Champagne is robust to the effects of high levels of noise, interference, and highly correlated brain source activity. Simulations demonstrate excellent performance of Smooth Champagne when compared to benchmark algorithms in accurately determining the spatial extent of distributed source activity. Smooth Champagne also accurately reconstructs real MEG and EEG data.

Citations

May 31, 2020·Otolaryngologic Clinics of North America·Meredith E AdamsSteven W Cheung
Jun 8, 2021·Frontiers in Human Neuroscience·Chang CaiSrikantan S Nagarajan
May 12, 2021·Ear and Hearing·Jolie L ChangSteven W Cheung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved