Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET

Medical Physics
Cristian SalinasGerald M Saidel

Abstract

Myocardial beta adrenergic receptor (beta-AR) concentration can substantially decrease in congestive heart failure and significantly increase in chronic volume overload, such as in severe aortic valve regurgitation. Positron emission tomography (PET) with an appropriate ligand-receptor model can be used for noninvasive estimation of myocardial beta-AR concentration in vivo. An optimal design of the experiment protocol, however, is needed for sufficiently precise estimates of beta-AR concentration in a heterogeneous population. Standard methods of optimal design do not account for a heterogeneous population with a wide range of beta-AR concentrations and other physiological parameters and consequently are inadequate. To address this, we have developed a methodology to design a robust two-injection protocol that provides reliable estimates of myocardial beta-AR concentration in normal and pathologic states. A two-injection protocol of the high affinity beta-AR antagonist [18F]-(S)-fluorocarazolol was designed based on a computer-generated (or synthetic) population incorporating a wide range of beta-AR concentrations. Timing and dosage of the ligand injections were optimally designed with minimax criterion to provide the least bad...Continue Reading

References

Apr 1, 1992·British Journal of Clinical Pharmacology·M R ChesterM Yacoub
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jacques DelforgeB Mazière
Mar 1, 1990·Journal of Gerontology·N TumerJ Roberts
Mar 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T StadlerH von Faber
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Dec 1, 1993·Pharmacology & Therapeutics·O E Brodde
Nov 15, 1993·Journal of the American College of Cardiology·D C LefroyP Nihoyannopoulos
Jan 1, 1994·Journal of Computer Assisted Tomography·K WienhardW D Heiss
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M J HayesJ M Hughes
Feb 24, 2001·Medical & Biological Engineering & Computing·Raymond F MuzicMarc Berridge
Aug 14, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·Raymond F MuzicMarc Berridge
Jan 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Richard M de JongDirk J van Veldhuisen
May 11, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Petra DozeAntoon T M Willemsen
Jan 18, 2003·Journal of Applied Physiology·Xi WangNaranjan S Dhalla
Apr 20, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bradley T ChristianJogeshwar Mukherjee
Sep 9, 2004·Circulation·Eric PlanteJacques Couet
Dec 14, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Richard M de JongPhilip H Elsinga
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Xi WangNaranjan S Dhalla
Jul 27, 2005·Journal of Cardiovascular Pharmacology·Cristian SalinasPaul Ernsberger
Jan 1, 1996·IEEE Transactions on Medical Imaging·Raymond F MuzicF Miraldi

Citations

May 20, 2014·Journal of Neuroimmunology·Katarina RadojevićGordana Leposavić
Aug 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ansel T HillmerBradley T Christian
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dustin W WootenBradley T Christian
Dec 31, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicholas T VandeheyBradley T Christian
Feb 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cristian SalinasRoger N Gunn
Jan 19, 2008·Clinical Pharmacology and Therapeutics·C T Dollery

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Jacques DelforgeA Syrota
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Dustin W WootenBradley T Christian
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Nicholas T VandeheyBradley T Christian
Nuclear Medicine and Biology
Dustin W WootenBradley T Christian
© 2021 Meta ULC. All rights reserved