Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses

Vaccine
Sohel ShamsuzzamanFirdausi Qadri

Abstract

The emergence of V. cholerae O139 serogroup of V. cholerae capable of causing severe dehydrating cholera has over the decade led to efforts in formulation of vaccines to protect against this pathogen. Although the prevalence of diarrhea due to V. cholerae O139 has recorded a decrease, efforts on vaccine development continues to formulate an oral vaccine capable of stimulating the gut mucosal system. We have studied the mucosal immunogenicity in Bangladeshi adults to a killed whole cell (WC) bivalent cholera vaccine composed of V. cholerae O139 as well as V. cholerae O1 strains together with the recombinant cholera toxin B subunit (CTB) (WC-O1/O139/CTB) and compared the immune responses to that obtained with the licensed monovalent cholera vaccine, Dukoral (WC-O1/CTB). Direct estimation of the WC-O1/O139/CTB vaccine-specific mucosal responses were carried out using lymphocytes isolated from duodenal biopsies, intestinal lavage fluid and feces. The vaccine induced robust antibody-secreting cell responses in the duodenum specific to CTB as well as the O1 and O139 lipopolysaccharide (LPS). Magnitude of response was higher in the gut than in the circulation in all three antibody isotypes. The CTB and LPS-specific mucosal antibody re...Continue Reading

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Citations

Sep 21, 2013·Human Vaccines & Immunotherapeutics·Rozita RosliSyahril Abdullah
Jan 21, 2011·Clinical and Vaccine Immunology : CVI·Taher UddinFirdausi Qadri
Jul 26, 2012·Nature Reviews. Immunology·Nils Lycke
Jun 17, 2016·PLoS Neglected Tropical Diseases·Wilfredo R MatiasJason B Harris
Apr 7, 2019·Mucosal Immunology·Christopher J H DavittEd C Lavelle
Jun 20, 2020·Gut Microbes·Hyesuk SeoWeiping Zhang

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