Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data methods, typically in a two-sample design. In addition to the conventional inverse variance weighting (IVW) method, recently developed summary data MR methods, such as the MR-Egger and weighted median approaches, allow a relaxation of the instrumental variable assumptions. Here, a new method - the mode-based estimate (MBE) - is proposed to obtain a single causal effect estimate from multiple genetic instruments. The MBE is consistent when the largest number of similar (identical in infinite samples) individual-instrument causal effect estimates comes from valid instruments, even if the majority of instruments are invalid. We evaluate the performance of the method in simulations designed to mimic the two-sample summary data setting, and demonstrate its use by investigating the causal effect of plasma lipid fractions and urate levels on coronary heart disease risk. The MBE presented less bias and lower type-I error rates than other...Continue Reading
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors.
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation
Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits
Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data
Mendelian randomisation and the goal of inferring causation from observational studies in the vision sciences
Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study.
Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization
Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective
Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.
Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail
The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis
Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study
Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight
Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis.
Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: A Bidirectional Mendelian Randomization Analysis
Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study
Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.
Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization.
Comparison of Genetic Liability for Sleep Traits Among Individuals With Bipolar Disorder I or II and Control Participants.
Application of the instrumental inequalities to a Mendelian randomization study with multiple proposed instruments
Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders
Investigation of Causal Effect of Atrial Fibrillation on Alzheimer Disease: A Mendelian Randomization Study
Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.
Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework.
Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study
Empirical comparisons of multiple Mendelian randomization approaches in the presence of assortative mating.
The median and the mode as robust meta-analysis estimators in the presence of small-study effects and outliers
The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study.
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches.
Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals
Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study.
Appraising causal relationships of dietary, nutritional and physical-activity exposures with overall and aggressive prostate cancer: two-sample Mendelian-randomization study based on 79 148 prostate-cancer cases and 61 106 controls.
A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia.
Bidirectional effects between loneliness, smoking and alcohol use: evidence from a Mendelian randomization study.
Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.
The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study.
Genetically, Dietary Sodium Intake Is Causally Associated with Salt-Sensitive Hypertension Risk in a Community-Based Cohort Study: a Mendelian Randomization Approach
Genetically predicted circulating concentrations of micro-nutrients and risk of breast cancer: A Mendelian randomization study
Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank
Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study.
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.
A comprehensive genetic and epidemiological association analysis of vitamin D with common diseases/traits in the UK Biobank.
Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization.
Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population.
Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization.
Adiposity and Cardiometabolic Outcomes: What Can Meta-analyses of Mendelian Randomization Studies Contribute?
Association Between Premorbid Body Mass Index and Amyotrophic Lateral Sclerosis: Causal Inference Through Genetic Approaches
Inferring the direction of a causal link and estimating its effect via a Bayesian Mendelian randomization approach
Serum albumin and atrial fibrillation: insights from epidemiological and mendelian randomization studies
Application of the Instrumental Inequalities to a Mendelian Randomization Study With Multiple Proposed Instruments.
Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.
Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.
Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium
Assessing causality in the association between attention-deficit/hyperactivity disorder and obesity: a Mendelian randomization study
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits.
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation
Birth weight is not causally associated with adult asthma: results from instrumental variable analyses
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study.
Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics
Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets
Roles for circulating polyunsaturated fatty acids in ischemic stroke and modifiable factors: a Mendelian randomization study
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic?
Assessing Causality in Associations of Serum Calcium and Magnesium Levels With Heart Failure: A Two-Sample Mendelian Randomization Study
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study.
The effects of age at menarche and first sexual intercourse on reproductive and behavioural outcomes: A Mendelian randomization study.
Mendelian Randomization Analysis Reveals a Causal Effect of Urinary Sodium/Urinary Creatinine Ratio on Kidney Function in Europeans.
Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics.
Modal-based estimation via heterogeneity-penalized weighting: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid
Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders
The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.
Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders.
Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours.
Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa.
Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.
Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk
Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study.
Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia
Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach.
Does smoking cause lower educational attainment and general cognitive ability? Triangulation of causal evidence using multiple study designs.
Using genetics to understand the role of antihypertensive drugs modulating angiotensin-converting enzyme in immune function and inflammation.
Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data
Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study.
Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a bidirectional and multivariable Mendelian randomization study with more than 815,000 participants.
Assessing the Relationship Between Leukocyte Telomere Length and Cancer Risk/Mortality in UK Biobank and TCGA Datasets With the Genetic Risk Score and Mendelian Randomization Approaches.
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.
Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study
A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder
Associations of Observational and Genetically Determined Caffeine Intake With Coronary Artery Disease and Diabetes Mellitus.
Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality
A Mendelian randomization of γ' and total fibrinogen levels on venous thromboembolism and ischemic stroke
Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources.
A comprehensive evaluation of methods for Mendelian randomization using realistic simulations and an analysis of 38 biomarkers for risk of type 2 diabetes
Mendelian Randomization in Cardiovascular Research: Establishing Causality When There Are Unmeasured Confounders
A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank.
Education and heart failure: New insights from the atherosclerosis risk in communities study and mendelian randomization study.
Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes.
Large-scale association analyses identify host factors influencing human gut microbiome composition.
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.
Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis.
Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment.
Are blood lipids risk factors for fracture? Integrative evidence from instrumental variable causal inference and mediation analysis using genetic data
The use of negative control outcomes in Mendelian randomization to detect potential population stratification.
Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.
Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study.
An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting.
MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data.
Exploring the Effects of Cigarette Smoking on Inflammatory Bowel Disease Using Mendelian Randomization.
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.
Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.
Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis.
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank
A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke.
Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.
MRCIP: a robust Mendelian randomization method accounting for correlated and idiosyncratic pleiotropy.
Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study.
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis.
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein(a) Concentration: Protective Missense Variant on Lipoprotein(a) Concentration-Brief Report.
Physical activity and the risk of rheumatoid arthritis: evidence from meta-analysis and Mendelian randomization.
Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study.
Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study.
Investigating the genetic and causal relationship between initiation or use of alcohol, caffeine, cannabis and nicotine.
Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank.
Response to: 'Correspondence on 'Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study' by Lee
Evaluation relationships between subjective wellbeing, personality traits, and Alzheimer's disease: A two-sample Mendelian randomization study.
Causal effects of plasma lipids on the risk of atrial fibrillation: A multivariable mendelian randomization study.
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.
Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.
A Mendelian Randomization Study of Plasma Homocysteine Levels and Cerebrovascular and Neurodegenerative Diseases.
Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study.
Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study.
Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study.
Genetic Predisposition to Type 2 Diabetes and Insulin Levels is Positively Associated with Serum Urate Levels.
Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders.
Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study.
Association of short sleep with risk of periodontal disease: A meta-analysis and Mendelian randomization study.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Spatio-Temporal Regulation of DNA Repair
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.
Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Hereditary Sensory Autonomic Neuropathy
Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Applications of Molecular Barcoding
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.