Robust labeling and comparative preclinical characterization of DOTA-TOC and DOTA-TATE

Nuclear Medicine and Biology
Irina VelikyanHåkan Hall

Abstract

Various radionuclide-labeled somatostatin analogues are used currently for diagnosis and therapy of neuroendocrine tumors. In particular, [68Ga]Ga-DOTA-TOC is commonly used for diagnosis, while [177Lu]Lu-DOTA-TATE is used for therapy. With the development of theranostics and personalized medicine where the imaging diagnosis is tailored to the subsequent radiotherapy, it is of paramount importance to investigate the relevance of the ligand exchange. The aim of this study was to compare binding capacity of [67/68Ga]Ga-DOTA-TOC ([67/68Ga]Ga-N-(4,7,10-(tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetyl-D-Phe-c[Cys-D-Tyr-Trp-Lys-Thr-Cys]-Thr(ol)) and [67/68Ga]Ga-DOTA-TATE ([67/68Ga]Ga-N-(4,7,10-(tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetyl-D-Phe-c[Cys-D-Tyr-Trp-Lys-Thr-Cys]-Thr) in vitro in monkey brain cryosections and in vivo in the rat, where, in contrast to transfected cell lines, there is a heterogeneous distribution of somatostatin receptor (SSTR) subtypes. The influence of various production methods of [68Ga]Ga-DOTA-TOC and [68Ga]Ga-DOTA-TATE on the biological performance of the tracers was also studied. [67Ga]Ga-DOTA-TOC, [68Ga]Ga-DOTA-TOC, [67Ga]Ga-DOTA-TATE and [68Ga]Ga-DOTA-TATE were synthesize...Continue Reading

References

Feb 1, 1986·Journal of Neurochemistry·M F BealJ B Martin
May 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Jan 1, 1996·Anti-cancer Drugs·K J O'Byrne, D N Carney
Oct 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Jul 1, 1997·European Journal of Nuclear Medicine·A OtteH R Maecke
Dec 5, 1997·Brain Research. Molecular Brain Research·L HelboeC E Stidsen
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiGiovanni Paganelli
Nov 20, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Damian WildMichael Hofmann
Feb 2, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Zarni WinAdil Al-Nahhas
Jan 17, 2007·European Journal of Nuclear Medicine and Molecular Imaging·P AntunesH Maecke
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Flavio ForrerEric P Krenning
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael GabrielIrene J Virgolini
Apr 7, 2007·Nuclear Medicine Communications·Zarni WinPhilip Gishen
Aug 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Adil Al-NahhasDomenico Rubello
Jan 8, 2008·The Lancet Oncology·Irvin M ModlinAnders Sundin
Apr 3, 2008·Contrast Media & Molecular Imaging·Melpomeni FaniHelmut R Maecke
Jul 1, 2008·Nuclear Medicine and Biology·Irina VelikyanBengt Långström
Sep 23, 2008·Expert Opinion on Pharmacotherapy·I M ModlinB I Gustafsson
Jan 23, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Zhaofei LiuXiaoyuan Chen
Feb 10, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M U KhanA Al-Nahhas
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bea WaserJean Claude Reubi
Jun 6, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Martina L ZalomEdward M Wolin
Oct 22, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni Lucignani, Emilio Bombardieri
Mar 30, 2010·Nuclear Medicine and Biology·Irina VelikyanBengt Långström
Jun 1, 2010·Nuclear Medicine Communications·Matthias BauwensAlfons Verbruggen
Aug 10, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mattias SandströmMark Lubberink
Jun 15, 2016·Molecular Imaging and Radionuclide Therapy·Elahe PirayeshMajid Assadi

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Citations

Mar 19, 2013·PloS One·Yanyan GuoLee Josephson
Jan 8, 2014·Theranostics·Irina Velikyan
Jul 21, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irina Velikyan
Oct 23, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Eduardo RomeroMiguel Angel Morcillo
Feb 18, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Irina Velikyan
Feb 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Olof ErikssonOlle Korsgren
Mar 28, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Deidré PrinceSietske Rubow
Apr 25, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Deidré PrinceSietske Rubow
May 19, 2014·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Krzysztof Kilian
Aug 23, 2017·Seminars in Nuclear Medicine·Isaac M JacksonStephen Thompson
Jan 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Irina VelikyanBarbro Eriksson
Dec 10, 2013·Inorganic Chemistry·Brian M ZeglisJason S Lewis

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