Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease

Journal of Neuroscience Methods
Jessica J SteventonDerek K Jones

Abstract

Huge advances have been made in understanding and addressing confounds in diffusion MRI data to quantify white matter microstructure. However, there has been a lag in applying these advances in clinical research. Some confounds are more pronounced in HD which impedes data quality and interpretability of patient-control differences. This study presents an optimised analysis pipeline and addresses specific confounds in a HD patient cohort. 15 HD gene-positive and 13 matched control participants were scanned on a 3T MRI system with two diffusion MRI sequences. An optimised post processing pipeline included motion, eddy current and EPI correction, rotation of the B matrix, free water elimination (FWE) and tractography analysis using an algorithm capable of reconstructing crossing fibres. The corpus callosum was examined using both a region-of-interest and a deterministic tractography approach, using both conventional diffusion tensor imaging (DTI)-based and spherical deconvolution analyses. Correcting for CSF contamination significantly altered microstructural metrics and the detection of group differences. Reconstructing the corpus callosum using spherical deconvolution produced a more complete reconstruction with greater sensitiv...Continue Reading

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Citations

Jun 1, 2016·Frontiers in Neuroscience·Owen R PhillipsMargherita Di Paola
Dec 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Christina AndicaShigeki Aoki
Feb 6, 2020·Current Medical Imaging Reviews·Rodolfo Gabriel Gatto, Carina Weissmann
Jul 1, 2020·Neurobiology of Disease·Daniel K Wilton, Beth Stevens
Aug 12, 2019·NeuroImage. Clinical·Audrey E De PaepeEstela Camara

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Software Mentioned

Camino
HD
SPSS Statistics
Explore DTI
PREDICT
elastix

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