Robust performance of deep learning for distinguishing glioblastoma from single brain metastasis using radiomic features: model development and validation.

Scientific Reports
Sohi BaeSeung-Koo Lee

Abstract

We evaluated the diagnostic performance and generalizability of traditional machine learning and deep learning models for distinguishing glioblastoma from single brain metastasis using radiomics. The training and external validation cohorts comprised 166 (109 glioblastomas and 57 metastases) and 82 (50 glioblastomas and 32 metastases) patients, respectively. Two-hundred-and-sixty-five radiomic features were extracted from semiautomatically segmented regions on contrast-enhancing and peritumoral T2 hyperintense masks and used as input data. For each of a deep neural network (DNN) and seven traditional machine learning classifiers combined with one of five feature selection methods, hyperparameters were optimized through tenfold cross-validation in the training cohort. The diagnostic performance of the optimized models and two neuroradiologists was tested in the validation cohort for distinguishing glioblastoma from metastasis. In the external validation, DNN showed the highest diagnostic performance, with an area under receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy of 0.956 (95% confidence interval [CI], 0.918-0.990), 90.6% (95% CI, 80.5-100), 88.0% (95% CI, 79.0-97.0), and 89.0% (95% CI, 8...Continue Reading

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Citations

Feb 2, 2021·Neuro-oncology Advances·Niha BeigPallavi Tiwari
Jun 25, 2021·Brain Research Bulletin·Edward R NevesSara Pedron

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Methods Mentioned

BETA
biopsy

Software Mentioned

TensorFlow
Python
Keras
WhiteStripe R
Learn
Medical Image Processing , Analysis , and Visualization
Scikit
R
RMSProp

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