Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia

IEEE Transactions on Bio-medical Engineering
Clara M IonescuJulio E Normey-Rico

Abstract

This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.

References

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Citations

Jun 1, 2011·British Journal of Anaesthesia·M M R F StruysA R Absalom
Nov 10, 2013·PLoS Computational Biology·Maryam M ShanechiEmery N Brown
Jun 12, 2013·Journal of Clinical Monitoring and Computing·Mengqi FangYouqing Wang
Jul 6, 2014·Computer Methods and Programs in Biomedicine·Pantelis SopasakisHaralambos Sarimveis
Nov 26, 2013·Journal of Clinical Monitoring and Computing·Clara M IonescuRobin De Keyser
May 3, 2015·IEEE Transactions on Bio-medical Engineering·Stamatina ZavitsanouEfstratios N Pistikopoulos
Aug 1, 2013·IEEE Transactions on Bio-medical Engineering·Alexandra KriegerEfstratios N Pistikopoulos
Nov 6, 2014·IEEE Transactions on Bio-medical Engineering·Ioana NascuEfstratios N Pistikopoulos
Feb 23, 2010·IEEE Transactions on Bio-medical Engineering·Gabriele PannocchiaAlberto Landi
Feb 12, 2013·Journal of Biomedical Informatics·J KretschmerK Möller
Jan 1, 2015·Computational and Mathematical Methods in Medicine·Ali KhaqanRaja Ali Riaz
Jun 11, 2016·Computer Methods and Programs in Biomedicine·Ana Gabriela Gallardo-HernandezSergio Islas-Andrade
Sep 21, 2016·Computer Methods and Programs in Biomedicine·Filipa N NogueiraP Rocha
Jul 10, 2013·Anesthesia and Analgesia·Guy A Dumont, J Mark Ansermino
Feb 26, 2011·Anesthesia and Analgesia·Anthony R AbsalomMichel M R F Struys
Oct 5, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Pantelis SopasakisAristides Dokoumetzidis
Apr 9, 2019·Biomedical Engineering Letters·Bhavina PatelAlpesh Sarvaia
Feb 19, 2019·IET Systems Biology·Maryam Boroujerdi Alavi, Mohammad Tabatabaei

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