Robust Self-Referencing Method for Chiral Sum Frequency Generation Spectroscopy

The Journal of Physical Chemistry. B
M Luke McDermott, Poul B Petersen

Abstract

Chiral sum frequency generation spectroscopy (SFG) is of great interest for studying biological systems, among others. Whereas the chiral response in circular dichroism is about 0.1% of the achiral response, the chiral SFG response can be the same order of magnitude as the achiral SFG signal. However, chiral SFG is limited by the attainable signal-to-noise of the weak nonlinear signals and therefore extremely sensitive to proper alignment. We present a robust method for chiral SFG and demonstrate the use on solid-air surfaces with achiral and chiral molecules. We simultaneously measure two orthogonal polarizations-either the interference chiral SFG (±45° polarized) or the pure chiral and achiral SFG-using a waveplate and beam displacer. Both optics are placed in the detection arm and can be easily incorporated into any SFG setup. Furthermore, we employ self-referencing to calibrate alignment for each sample individually using a polarizer in the detection arm. These methods greatly increase the reliability and quality of chiral SFG measurements.

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Citations

Jan 14, 2017·The Journal of Physical Chemistry Letters·Yuchen Sun, Poul B Petersen
Feb 3, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Stephanie E SandersPoul B Petersen
Mar 28, 2018·Science Advances·Istvan KocsisMihail Barboiu
Oct 3, 2018·Optics Letters·Isaac G Prichett, Aaron M Massari
Aug 25, 2016·Optics Express·Patrick M KearnsAaron M Massari
May 28, 2021·The Journal of Physical Chemistry. B·Rodrigo Noriega
Aug 5, 2017·ACS Central Science·M Luke McDermottPoul B Petersen
Oct 1, 2016·The Journal of Physical Chemistry Letters·Konrad MeisterHuib J Bakker

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