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Robustness can evolve gradually in complex regulatory gene networks with varying topology

PLoS Computational Biology

Feb 6, 2007

S CilibertiAndreas Wagner

Abstract

The topology of cellular circuits (the who-interacts-with-whom) is key to understand their robustness to both mutations and noise. The reason is that many biochemical parameters driving circuit behavior vary extensively and are thus not fine-tuned. Existing work in this area asks to wha...read more

Mentioned in this Paper

Embryo
In Silico
Transcriptional Regulation
Entire Embryo
One Step (dimethicone)
Transcription, Genetic
Spearman Correlation Test
One-Step Dentin Bonding System
Drosophila
Chemotaxis
2
362
Paper Details
References
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  • Citations161
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  • References62
  • Citations161
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Robustness can evolve gradually in complex regulatory gene networks with varying topology

PLoS Computational Biology

Feb 6, 2007

S CilibertiAndreas Wagner

PMID: 17274682

DOI: 10.1371/journal.pcbi.0030015

Abstract

The topology of cellular circuits (the who-interacts-with-whom) is key to understand their robustness to both mutations and noise. The reason is that many biochemical parameters driving circuit behavior vary extensively and are thus not fine-tuned. Existing work in this area asks to wha...read more

Mentioned in this Paper

Embryo
In Silico
Transcriptional Regulation
Entire Embryo
One Step (dimethicone)
Transcription, Genetic
Spearman Correlation Test
One-Step Dentin Bonding System
Drosophila
Chemotaxis
2
362

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Evolution of Gene Regulation (Keystone)

The evolution from single-celled to multicellular organisms required precise control of genes and gave cells the ability to be programmed for specific functions. Discover the latest research on the evolution of gene regulation and gene regulation in Drosophila in this feed.

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Paper Details
References
  • References62
  • Citations161
12345...
  • References62
  • Citations161
12345...
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