Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations.

Neural Systems & Circuits
Fabio M Simões de Souza, Erik De Schutter

Abstract

Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs. Isolated GoCs coupled by gap junctions had a strong tendency to generate spontaneous oscillations without affecting their mean firing frequencies in response to distributed mossy fiber input. Conversely, when GoCs were synaptically connected in the granular layer, gap junctions increased the power of the oscillations, but the oscillations were primarily driven by the synaptic feedback loop between GoCs and GCs, and the gap junctions did not change oscillation frequency or the mean firing rate of either GoCs or GCs. Our modeling results suggest that gap junctions between GoCs increase the robustness of cerebellar cortex oscillations that are primarily driven by the feedback loop betwe...Continue Reading

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Citations

May 9, 2012·Alcoholism, Clinical and Experimental Research·Jian-Jia HuangChiming Huang
May 6, 2016·Frontiers in Computational Neuroscience·Anna CattaniClaudio Canuto
Jul 28, 2016·Frontiers in Cellular Neuroscience·Egidio D'AngeloEduardo Ros
Apr 20, 2017·The Cerebellum·Jennifer Claire RobinsonRichard Courtemanche
Sep 22, 2017·PLoS Computational Biology·Shyam Kumar SudhakarErik De Schutter
Dec 4, 2019·Frontiers in Molecular Neuroscience·Francesca PrestoriEgidio D'Angelo
Nov 27, 2020·Frontiers in Systems Neuroscience·Maxime LévesqueRichard Courtemanche
Apr 11, 2020·Current Biology : CB·Anila M D'MelloDerek Evan Nee

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