Robustness of linkage maps in natural populations: a simulation study.

Proceedings. Biological Sciences
Jon Slate

Abstract

In a number of long-term individual-based studies of vertebrate populations, the genealogical relationships between individuals have been established with molecular markers. As a result, it is possible to construct genetic linkage maps of these study populations by examining the co-segregation of markers through the pedigree. There are now four free-living vertebrate study populations for whom linkage maps have been built. In this study, simulation was used to investigate whether these linkage maps are likely to be accurate. In all four populations, the probability of assigning markers to the correct chromosome is high and framework maps are generally inferred correctly. However, genotyping error can result in incorrect maps being built with very strong statistical support over the correct order. Future applications of linkage maps of natural populations are discussed.

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Citations

Sep 10, 2008·Genetica·Jon SlateJosephine M Pemberton
Jan 24, 2008·Proceedings. Biological Sciences·J M Pemberton
Jan 24, 2008·Proceedings. Biological Sciences·L E B Kruuk, W G Hill
Oct 4, 2012·BMC Genomics·Meredith V EverettJames E Seeb
Jul 27, 2010·International Journal of Law and Psychiatry·Elizabeth Richardson, Bernadette McSherry
Apr 14, 2015·Molecular Ecology Resources·Pirmin NietlisbachErik Postma
Oct 29, 2011·Evolutionary Anthropology·Brenda J Bradley, Richard R Lawler
Nov 8, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jessica StapleyCarole M Smadja
Jun 20, 2017·G3 : Genes - Genomes - Genetics·Ben J G SutherlandLouis Bernatchez

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