Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mikko VähäsöyrinkiMikko Juusola

Abstract

Determining the contribution of a single type of ion channel to information processing within a neuron requires not only knowledge of the properties of the channel but also understanding of its function within a complex system. We studied the contribution of slow delayed rectifier K+ channels to neural coding in Drosophila photoreceptors by combining genetic and electrophysiological approaches with biophysical modeling. We show that the Shab gene encodes the slow delayed rectifier K+ channel and identify a novel voltage-gated K+ conductance. Analysis of the in vivo recorded voltage responses together with their computer-simulated counterparts demonstrates that Shab channels in Drosophila photoreceptors attenuate the light-induced depolarization and prevent response saturation in bright light. We also show that reduction of the Shab conductance in mutant photoreceptors is accompanied by a proportional drop in their input resistance. This reduction in input resistance partially restores the signaling range, sensitivity, and dynamic coding of light intensities of Shab photoreceptors to those of the wild-type counterparts. However, loss of the Shab channels may affect both the energy efficiency of coding and the processing of natur...Continue Reading

Citations

Apr 11, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Antti VähäkainuMatti Weckström
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
Mar 22, 2007·PLoS Biology·Jeremy E NivenSimon B Laughlin
Jul 16, 2010·PLoS Computational Biology·Amber E Hudson, Astrid A Prinz
Apr 16, 2011·PloS One·Jouni TakaloMikko Vähäsöyrinki
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paloma T Gonzalez-BellidoMikko Juusola
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmad N Abou TayounPatrick J Dolph
Sep 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunbing Zhao, Jorge Golowasch
May 23, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhuoyi Song, Mikko Juusola
Jun 20, 2014·PLoS Computational Biology·Anca Doloc-Mihu, Ronald L Calabrese
Jan 9, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Roman V FrolovMatti Weckström
Nov 28, 2012·Journal of Neurogenetics·Roman V FrolovSatpal Singh
Aug 14, 2009·The European Journal of Neuroscience·Rafael KurtzMartin Egelhaaf
Sep 6, 2006·EMBO Reports·Kyriaki SidiropoulouPanayiota Poirazi
Jun 19, 2012·Current Biology : CB·Zhuoyi SongMikko Juusola
Mar 11, 2008·Current Biology : CB·Rikard FrederiksenEric J Warrant
Nov 28, 2012·Journal of Physiology, Paris·Anne-Kathrin WarzechaJan Grewe
Jan 15, 2017·The Journal of Physiology·Esa-Ville ImmonenRoman V Frolov
Aug 31, 2012·Journal of Neurophysiology·K HeimonenM Weckström
Feb 25, 2017·The Journal of Physiology·Mikko Juusola, Zhuoyi Song
Feb 15, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna HonkanenMatti Weckström
Dec 12, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Burak GürMarion Silies
Feb 13, 2016·Journal of Neurophysiology·Roman FrolovMatti Weckström
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May 21, 2008·The Journal of Experimental Biology·Jeremy E Niven, Simon B Laughlin

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