Robustness of VMAT and 3DCRT plans toward setup errors in radiation therapy of locally advanced left-sided breast cancer with DIBH

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Christer A JensenJomar Frengen

Abstract

The aim of our study was to evaluate and compare the robustness of treatment plans produced using the volumetric modulated arc-therapy (VMAT) and the standard three-dimensional conformal radiotherapy (3DCRT) techniques by estimating perturbed doses induced by localization offsets for deep inspiration breath-hold (DIBH) in locally advanced breast cancer radiation therapy. Twenty patients with left breast carcinoma requiring radiation therapy were analysed in this planning study. Robust VMAT plans regarding minimum CTV doses and standard 3DCRT plans were produced, and perturbed doses were calculated in accordance with localization values from the weekly offline imaging protocol. Offsets from 5 weeks were summed to a perturbed overall treatment plan. Dose criteria for evaluation were coverage and homogeneity of the target, as well as doses to organs at risk. VMAT plans resulted in significantly better target coverage compared to 3DCRT, as well as lowered doses to heart and left anterior descending artery, while the perturbed doses were less variable for VMAT than 3DCRT plans. Homogeneity was significantly improved in VMAT plans. The statistical analysis taking all organs into account found that VMAT plans were more robust than 3DC...Continue Reading

Citations

Jul 1, 2018·Journal of Applied Clinical Medical Physics·Marguerite TyranHugues Mailleux
Nov 13, 2018·Physics in Medicine and Biology·Jan UnkelbachHuijun Xu
Apr 22, 2020·Technology in Cancer Research & Treatment·Haijiao ShangYuenan Wang
Apr 24, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Hideharu MiuraYasushi Nagata
Feb 28, 2021·Journal of Applied Clinical Medical Physics·Christer A JensenChristoffer Lervåg
Jun 18, 2020·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Toru TakakuraMasahiko Koizumi

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