ROCK as a Therapeutic Target of Diabetic Retinopathy.

Journal of Ophthalmology
Ryoichi AritaTatsuro Ishibashi

Abstract

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.

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Jan 28, 2014·PloS One·Guorong LinKathleen M Macleod
Feb 11, 2011·Diabetes/metabolism Research and Reviews·Hong Zhou, Yongjun Li
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Mar 6, 2021·Journal of Experimental Pharmacology·Ghadeer Al-HumimatKaranjit Kooner
Feb 20, 2021·Current Opinion in Ophthalmology·Zeba A Syed, Christopher J Rapuano

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