ROCK2 promotes HCC proliferation by CEBPD inhibition through phospho-GSK3β/β-catenin signaling

FEBS Letters
Ming LiJianghua Shao

Abstract

Rho-associated kinase 2 (Rock2) is known to promote tumorigenesis in hepatocellular carcinoma (HCC). CCAAT/enhancer-binding protein delta (CEBPD) functions as a tumor suppressor. In this study, we found that the expression of Rock2 and CEBPD are inversely correlated. Knockdown of Rock2 increased CEBPD expression and inhibited the proliferation of HCC cells in vitro and in vivo. Mechanistically, we found that Rock2 regulates CEBPD expression through the p-GSK3β/β-catenin pathway. Taken together, we identified a novel Rock2-p-GSK3β/β-catenin-CEBPD regulatory circuitry, the dysfunction of which may contribute to the tumorigenic characteristic of HCC.

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Citations

Feb 27, 2020·Genetic Epidemiology·Daniel C PosnerJosée Dupuis
Apr 2, 2020·Cells·Leonie HoffmeisterRené Huber
Oct 21, 2016·Oncotarget·Daniela D'ArcangeloAntonio Facchiano
Mar 5, 2021·Life Science Alliance·Elena A AfanasyevaFrank Westermann

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