Rocuronium pharmacokinetic-pharmacodynamic relationship under stable propofol or isoflurane anesthesia

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Alexandrina DragneFrançois Donati

Abstract

To compare the pharmacokinetics, pharmacodynamics and the concentration-effect relationship of rocuronium in patients under stable propofol or isoflurane anesthesia. Ten patients were randomized to receive fentanyl, propofol and nitrous oxide (60%) or fentanyl, thiopental, isoflurane (1.2% end-tidal concentration) and nitrous oxide (60%). To obtain good intubation conditions and maintain adequate muscle relaxation during surgery, patients received two bolus doses of rocuronium: 0.5 mg x kg(-1) (1.7 x ED95) at induction followed one hour later by 0.3 mg x kg(-1) (1 x ED95). Arterial blood samples were obtained over six hours after the second bolus dose. Plasma concentrations of rocuronium were measured using high pressure liquid chromatography. Muscle twitch tension was monitored by mechanomyography for the two doses. Pharmacokinetic and pharmacodynamic parameters were determined. No differences in rocuronium pharmacokinetic parameters were observed between both groups. After the second bolus, clinical duration was 20 +/- 6 min in the propofol group vs 39 +/- 8 min in the isoflurane group (P <0.05). The effect compartment concentration corresponding to 50% block, EC50, was higher under propofol anesthesia: 1008 vs 592 microg x L...Continue Reading

Associated Clinical Trials

References

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Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yuhji SaitohMasahiro Murakawa
Dec 29, 2013·Journal of Pharmaceutical and Biomedical Analysis·Natália Valadares de MoraesVera Lucia Lanchote
Feb 6, 2016·Acta Anaesthesiologica Scandinavica·Aaron F Kopman, Mohamed Naguib
Feb 24, 2016·Acta Anaesthesiologica Scandinavica·E A VegaL I Cortínez
Oct 21, 2016·The Journal of Pharmacy and Pharmacology·Renan M VarriqueNatalia V de Moraes
Apr 26, 2006·Veterinary Anaesthesia and Analgesia·Shotaro NagahamaNobuo Sasaki
Apr 23, 2005·Anesthesia and Analgesia·Aaron F KopmanRawshan Malik
Jan 23, 2009·European Journal of Anaesthesiology·Harald IhmsenTino Muenster
Feb 1, 2005·European Journal of Anaesthesiology·P G MaidatsiM M Giala
Feb 1, 2019·The Journal of Veterinary Medical Science·Hisashi SakataKazuto Yamashita

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