Rod-shaped mesoporous silica nanoparticles for nanomedicine: recent progress and perspectives

Expert Opinion on Drug Delivery
Vu Thanh CongJ Justin Gooding

Abstract

Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod-shaped mesoporous silica nanoparticles show improvements in drug delivery relative to spherical mesoporous silica nanoparticles. This review summarises the synthesis methods for producing rod-shaped mesoporous silica nanoparticles for use in nanomedicine. The second part covers recent progress of mesoporous silica nanorods by comparing the impact of sphere and rod-shape on drug delivery efficiency. As hollow mesoporous silica nanorods are capable of higher drug loads than most other drug delivery vehicles, such particles will reduce the amount of mesoporous silica in the body for efficient therapy. However, the importance of nanoparticle shape on drug delivery efficiency is not well understood for mesoporous silica. Studies that visualize and quantify the uptake pathway of mesoporous silica nanorods in specific cell types and compare the cellular uptake to the well-studied nanospheres should be the focus of research to better...Continue Reading

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Citations

Sep 19, 2020·International Journal of Nanomedicine·Yuanyuan WangYumeng Wei
Nov 15, 2020·Colloids and Surfaces. B, Biointerfaces·Dajun XuDawei Deng
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo
Mar 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Delaram BabadiAzadeh Haeri
Apr 27, 2021·Nano Today·Jinping WangHongjun Wang
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanting SunChunyan Dong
Nov 8, 2020·International Journal of Pharmaceutics·Céline JaudoinAmélie Bochot

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