Rod shaped nanocrystals exhibit superior in vitro dissolution and in vivo bioavailability over spherical like nanocrystals: a case study of lovastatin

Colloids and Surfaces. B, Biointerfaces
Mengran GuoLi Yang

Abstract

The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocrystals for oral administration. Lovastatin (LOV) was chosen as the model drug and LOV rod shaped nanocrystals (LOV-RNs) and spherical like nanocrystals (LOV-SNs) were prepared by sonoprecipitation and bead milling, respectively. The dry powders obtained following freeze-drying were characterized by hydrodynamic diameter, polydispersity index, zeta potential, transmission electron microscope, scanning electron microscope, atomic force microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy, and in vitro dissolution test. The pharmacokinetic study was performed in beagle dogs. The results obtained showed that LOV-RNs and LOV-SNs had similar hydrodynamic diameters (500.6±21.0 nm versus 503.2±20.4 nm), and the same crystalline state. The dissolution test showed that LOV-RNs had a higher dissolution rate than LOV-SNs. The AUC(0-24h) values of LOV-RNs and LOV-SNs were higher than Junning® for both LOV (p<0.05 for LOV-RNs, and p>0.05 for LOV-SNs) and lovastatin acid (p>0.05). More importantly, the oral bioavailability of LOV-RNs was higher than LOV-SNs (p>0.05). The findings of this stud...Continue Reading

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Citations

Mar 25, 2016·Colloids and Surfaces. B, Biointerfaces·Jeong-Joo ParkBeom-Jin Lee
May 24, 2016·Pharmaceutics·Annika TuomelaLeena Peltonen
Apr 2, 2017·Drug Delivery and Translational Research·Wenqian YangZhonggui He
Feb 17, 2018·Drug Delivery and Translational Research·Yanyan LiuYanhua Li
Jan 28, 2017·AAPS PharmSciTech·Mai Khanfar, Suhair Al-Nimry
Aug 19, 2017·Nanoscale Research Letters·Maria MirFakhar Ud Din
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela

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