Rodent cell transformation and immediate early gene expression following 60-Hz magnetic field exposure

Environmental Health Perspectives
E K Balcer-KubiczekC C Davis

Abstract

Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces changes in gene expression that can result in neoplastic transformation. Twenty-four hour 200 microT continuous MF exposure produced negative results in two standard transformation systems (Syrian hamster embryo cells and C3H/10T1/2 murine fibroblasts) with or without postexposure to a chemical promoter. This prompted a reexamination of previously reported MF-induced changes in gene expression in human HL60 cells. Extensive testing using both coded and uncoded analyses was negative for an MF effect. Using the same exposure conditions as in the transformation studies, no MF-induced changes in ornithine decarboxylase expression were observed in C3H/10T1/2 cells, casting doubt on a promotional role of MF for the tested cells and experimental conditions.

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Citations

May 9, 2000·Biochemical and Biophysical Research Communications·J MiyakoshiG R Ding
Mar 21, 2006·International Journal of Radiation Biology·Jukka JuutilainenJonne Naarala
Feb 1, 2000·Bioelectromagnetics·S Engström, M Lindgren
Sep 5, 2002·Journal of Cellular Biochemistry·Joshua M ShallomTheodore A Litovitz
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May 4, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Giulia CallegaroFederico M Stefanini

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