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Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans

Critical Reviews in Toxicology

Apr 23, 1999

J C CookPaul M Foster

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Abstract

Leydig cells (LCs) are the cells of the testis that have as their primary function the production of testosterone. LCs are a common target of compounds tested in rodent carcinogenicity bioassays. The number of reviews on Leydig cell tumors (LCTs) has increased in recent years because of...read more

Mentioned in this Paper

PRL
Biochemical Pathway
Dopamine Agonists [MoA]
Testosterone Measurement
Benign Neoplasm of Testis
Ethanol
CYP19A1 gene
Ethanol Measurement
Cytological Techniques
Test, Cytology, Digestive
29
Paper Details
References
  • References280
  • Citations72
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  • References280
  • Citations72
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Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans

Critical Reviews in Toxicology

Apr 23, 1999

J C CookPaul M Foster

PMID: 10213111

DOI: 10.1080/10408449991349203

Abstract

Leydig cells (LCs) are the cells of the testis that have as their primary function the production of testosterone. LCs are a common target of compounds tested in rodent carcinogenicity bioassays. The number of reviews on Leydig cell tumors (LCTs) has increased in recent years because of...read more

Mentioned in this Paper

PRL
Biochemical Pathway
Dopamine Agonists [MoA]
Testosterone Measurement
Benign Neoplasm of Testis
Ethanol
CYP19A1 gene
Ethanol Measurement
Cytological Techniques
Test, Cytology, Digestive
29

Feeds With Similar Papers

Hormone-Related Cancers

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A mathematical model of production, distribution, and metabolism of melatonin in mammalian systems

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G M BlumenthalC J Portier
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Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator Wyeth-14,643

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Paper Details
References
  • References280
  • Citations72
12345...
  • References280
  • Citations72
12345...

Download from

Publisher
PubMed
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