PMID: 12911715Aug 13, 2003Paper

Rodent models for ovarian cancer research

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
K D Sloan Stakleff, V E Von Gruenigen

Abstract

Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.

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Citations

Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aparna YellapaAnimesh Barua
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K D Sloan StakleffV E Von Gruenigen
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Sep 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Thaïs BaertAn Coosemans
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Animesh BaruaJudith L Luborsky
Jun 11, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Animesh BaruaJudith L Luborsky
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