Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibility

Environmental Health Perspectives
U P KodavantiP A Bromberg

Abstract

The mechanisms by which increased mortality and morbidity occur in individuals with preexistent cardiopulmonary disease following acute episodes of air pollution are unknown. Studies involving air pollution effects on animal models of human cardiopulmonary diseases are both infrequent and difficult to interpret. Such models are, however, extensively used in studies of disease pathogenesis. Primarily they comprise those developed by genetic, pharmacologic, or surgical manipulations of the cardiopulmonary system. This review attempts a comprehensive description of rodent cardiopulmonary disease models in the context of their potential application to susceptibility studies of air pollutants regardless of whether the models have been previously used for such studies. The pulmonary disease models include bronchitis, emphysema, asthma/allergy, chronic obstructive pulmonary disease, interstitial fibrosis, and infection. The models of systemic hypertension and congestive heart failure include: those derived by genetics (spontaneously hypertensive, Dahl S. renin transgenic, and other rodent models); congestive heart failure models derived by surgical manipulations; viral myocarditis; and cardiomyopathy induced by adriamycin. The charact...Continue Reading

References

Oct 1, 1977·Environmental Research·R EhrlichD E Gardner
Jul 1, 1977·Japanese Heart Journal·Y Yamori
May 11, 1992·Proceedings of the Society for Experimental Biology and Medicine·E A ChasteneyW B Hood
Jan 1, 1992·Critical Reviews in Toxicology·D W WilsonD Morin
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D GantenU Ganten
Jul 1, 1992·International Journal of Immunopharmacology·J P TarayreJ Tisne-Versailles
Jan 1, 1992·Respiration; International Review of Thoracic Diseases·P K Jeffery
Nov 1, 1991·The American Review of Respiratory Disease·C L Rochester, J A Rankin
May 1, 1990·The American Review of Respiratory Disease·J L MauderlyR K Wolff
Jan 1, 1991·Archives of Toxicology·J HayG Laurent
Jan 1, 1991·Toxicologic Pathology·M Rabinovitch
Jul 1, 1991·Toxicology and Applied Pharmacology·A E SchultzeR A Roth
Sep 1, 1991·The American Review of Respiratory Disease·B Jany, C B Basbaum
Sep 1, 1991·Journal of Medical Microbiology·I MaciverT O'Reilly
Feb 1, 1991·Experimental and Molecular Pathology·J C RussellP J Dolphin
Oct 1, 1991·Journal of Toxicology and Environmental Health·J P Ehrlich, G R Burleson
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·C D WegnerR H Gundel
Jun 1, 1991·Toxicology and Applied Pharmacology·A E SchultzeR A Roth
Sep 1, 1990·The Journal of Experimental Medicine·A G Harmsen, M Stankiewicz
May 1, 1990·The American Review of Respiratory Disease·G J Jakab, D J Bassett
Jan 1, 1988·British Journal of Anaesthesia·M C Blom-MuilwijkA W Konings
Jan 1, 1988·Annual Review of Medicine·J A CooperR A Matthay
Mar 11, 1989·Lancet·W R RocheS T Holgate
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Jun 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M H KarolC Magreni
May 1, 1988·The American Review of Respiratory Disease·D H EidelmanJ G Martin
May 1, 1988·Toxicology and Applied Pharmacology·R A Roth, P E Ganey
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·F RiedelC H Rieger
Oct 1, 1988·Journal of Medical Virology·B S GrahamD T Karzon
Nov 1, 1988·The American Review of Respiratory Disease·L DiamondD W Winsett
Jan 1, 1988·Journal of Toxicology and Environmental Health·G J Jakab, R R Hmieleski
May 1, 1988·The American Journal of Cardiology·R FagardA Amery

❮ Previous
Next ❯

Citations

Apr 5, 2003·Toxicology Letters·Daniel L Costa, Urmila P Kodavanti
Jun 19, 2004·Inhalation Toxicology·Clarke G TankersleyRichard Rabold
Sep 14, 2002·Journal of Toxicology and Environmental Health. Part a·Srikanth S Nadadur, Urmila P Kodavanti
Jul 29, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rajiv K SaxenaUrmila P Kodavanti
Feb 8, 2003·Environmental Health Perspectives·Tsun-Jen ChengChang-Chuan Chan
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Urmila P KodavantiDaniel L Costa
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Matthew J CampenWilliam P Watkinson
Dec 14, 2002·Journal of Biochemical and Molecular Toxicology·David B Carlson, Gary H Perdew
Dec 22, 2005·Journal of Occupational Health·Chuen-Chau ChangTsun-Jen Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.