Rodent models of impulsive-compulsive behaviors in Parkinson's disease: How far have we reached?

Neurobiology of Disease
M Angela CenciHanna S Lindgren

Abstract

There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive-compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on uncertainties regarding, on one hand, the pathophysiology of these behaviors and, on the other hand, the experimental paradigms with which similar features can be induced in rodents. To help compose these uncertainties, we will here review the characteristics of ICBs in PD patients and then describe behavioral methods to approximate them in rodents. We will discuss both the challenges and the possibilities of applying these methods to animals with PD-like lesions, and review the recent progress made to t...Continue Reading

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Citations

Apr 20, 2017·Frontiers in Psychology·Susana Jiménez-MurciaFernando Fernández-Aranda
Mar 8, 2018·Journal of Neural Transmission·Ana MarquesPierre-Olivier Fernagut
Aug 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Elena EspaM Angela Cenci
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Nov 18, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Tiago F OuteiroAngela M Cenci
Apr 10, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Celeste NapierAmanda L Persons

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