Roflumilast: A Review in COPD

Drugs
Karly P Garnock-Jones

Abstract

Roflumilast (Daliresp®, Daxas®) is a selective phosphodiesterase 4 (PDE4) inhibitor that decreases systemic and pulmonary inflammation and improves disease symptoms in patients with severe chronic obstructive pulmonary disease (COPD). This article reviews the pharmacological properties of roflumilast and its clinical efficacy and tolerability in patients with COPD. Roflumilast is an effective treatment in patients with moderate to severe COPD; it improves lung function and is generally associated with a lower risk of exacerbation, particularly in patients with more severe disease and/or chronic bronchitis, cough and sputum. It is generally well tolerated; the most common adverse event was diarrhoea. While associated with an increased risk of psychiatric adverse events and weight loss, roflumilast is not associated with an increased risk of respiratory disease and infection, and may decrease the risk of cardiovascular adverse events. Roflumilast is a useful addition to the treatment options for patients with COPD.

References

Feb 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·UNKNOWN Asia Pacific COPD Roundtable Group
Jun 18, 2005·American Journal of Respiratory and Critical Care Medicine·Piero A MartoranaGiuseppe Lungarella
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Peter M A CalverleyLeonardo M Fabbri
Sep 1, 2009·Lancet·Peter M A CalverleyUNKNOWN M2-124 and M2-125 study groups
Dec 24, 2010·International Journal of Clinical Pharmacology and Therapeutics·T D Bethke, G Lahu
May 19, 2011·Expert Opinion on Drug Safety·Andreas HuennemeyerGezim Lahu
May 27, 2011·International Journal of Clinical Pharmacology and Therapeutics·N McCrackenT D Bethke
Jul 9, 2011·The European Respiratory Journal·E D BatemanL M Fabbri
Aug 19, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sang-Do LeeHan-Pin Kuo
Oct 4, 2011·The European Respiratory Journal·Denis E O'DonnellKatherine A Webb
Apr 14, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Nadine HertelKevin Jameson
Nov 3, 2012·Chest·Jadwiga A WedzichaPeter M A Calverley
Feb 7, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Yevgeniy SamyshkinMatthew Radford
Feb 9, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Yevgeniy SamyshkinEric D Bateman
Sep 13, 2013·Mediators of Inflammation·Daniela VecchioConcetta Gardi
Dec 19, 2013·Thorax·Tsung YuMilo A Puhan
Jan 1, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Caitlyn T SolemXin Gao
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Javier MilaraJulio Cortijo
May 9, 2014·Current Opinion in Pharmacology·Mark A Giembycz, Donald H Maurice
Jul 16, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Stephen I RennardPeter M A Calverley

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Citations

Dec 31, 2015·Current Opinion in Pulmonary Medicine·Derek W RussellJ Edwin Blalock
May 14, 2016·Expert Opinion on Drug Discovery·Mario CazzolaMaria Gabriella Matera
Jun 10, 2016·Expert Opinion on Drug Safety·Paola RoglianiMaria Gabriella Matera
Feb 15, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Akihiro TakanoChrister Halldin
Mar 6, 2019·Allergy·Peter J Barnes
Jul 22, 2018·Circulation·Toru HashimotoDavid A Kass
Mar 7, 2020·The Korean Journal of Internal Medicine·Chin Kook Rhee, Deog Kyeom Kim
Jul 31, 2020·Expert Review of Respiratory Medicine·Peter J Barnes
Feb 26, 2019·Frontiers in Molecular Neuroscience·Mark E Gurney
Mar 17, 2018·Analytical and Bioanalytical Chemistry·David BonnelKim T Nielsen
Aug 8, 2018·Chinese Medical Journal·Han-Rong FengSong-Min Ying
Aug 29, 2020·European Journal of Pharmacology·Takashi MatsuhiraYuji Tohda
Jan 12, 2020·Pharmacology & Therapeutics·Claire LugnierBernard Geny
Jun 13, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chia George HsuChen Yan

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