Rohon-Beard sensory neurons are induced by BMP4 expressing non-neural ectoderm in Xenopus laevis

Developmental Biology
Christy Cortez RossiKristin Bruk Artinger

Abstract

Rohon-Beard mechanosensory neurons (RBs), neural crest cells, and neurogenic placodes arise at the border of the neural- and non-neural ectoderm during anamniote vertebrate development. Neural crest cells require BMP expressing non-neural ectoderm for their induction. To determine if epidermal ectoderm-derived BMP signaling is also involved in the induction of RB sensory neurons, the medial region of the neural plate from donor Xenopus laevis embryos was transplanted into the non-neural ventral ectoderm of host embryos at the same developmental stage. The neural plate border and RBs were induced at the transplant sites, as shown by expression of Xblimp1, and XHox11L2 and XN-tubulin, respectively. Transplantation studies between pigmented donors and albino hosts showed that neurons are induced both in donor neural and host epidermal tissue. Because an intermediate level of BMP4 signaling is required to induce neural plate border fates, we directly tested BMP4's ability to induce RBs; beads soaked in either 1 or 10 ng/ml were able to induce RBs in cultured neural plate tissue. Conversely, RBs fail to form when neural plate tissue from embryos with decreased BMP activity, either from injection of noggin or a dominant negative BMP ...Continue Reading

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Citations

Mar 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christy Cortez RossiKristin Bruk Artinger
Nov 12, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bo YanSally A Moody
Sep 14, 2010·Genesis : the Journal of Genetics and Development·Eugenia OlesnickyKristin Bruk Artinger
Nov 23, 2011·The European Journal of Neuroscience·Cédric Patthey, Lena Gunhaga
Sep 3, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Carlene DyerRobert Knight
Sep 3, 2013·Developmental Biology·Alissa M Hulstrand, Douglas W Houston
Dec 17, 2011·Developmental Biology·Byung-Yong ParkJean-Pierre Saint-Jeannet
Jun 22, 2011·Developmental Biology·Laura Hernandez-LagunasKristin Bruk Artinger
Sep 10, 2009·Nature Reviews. Neuroscience·Linda Z Holland
Jun 21, 2020·Molecular Carcinogenesis·Ritsuko IwanagaKristin Bruk Artinger
Oct 22, 2010·Cell Adhesion & Migration·Michael W KlymkowskyKristin Bruk Artinger
Jun 7, 2012·Development·Tobias Hohenauer, Adrian W Moore
Aug 1, 2013·Development·Davalyn R PowellKristin Bruk Artinger

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