Rohypnol ("roofies") control of drug discrimination: effect of coadministered ethanol or flumenazil

Pharmacology, Biochemistry, and Behavior
M D Schechter

Abstract

The benzodiazepine flunitrazepam (Rohypnol) was employed to control differentially discriminative performance in 10 Sprague-Dawley rats on a food-motivated FR10 schedule. The training dose was 2.5 mg/kg, and 20 min was employed between intraperitoneal administration and training; both values were employed in this study, which, in reality, is the first time in the drug discrimination literature for the training of this drug. Dose-response experiments indicated decreasing discriminative performance in concert with decreasing time to reach FR10 lever selection as the dose tested decreased from 2.5 to 0.04 mg/kg. The calculated ED50 for discriminative performance, i.e., lever selection of the drug-correct lever, was 0.076 mg/kg. The relatively few sessions needed to reach discrimination criterion, and the fact that the ED50 value was 1/33 of the training dose, suggests that a lower dose of Rohypnol may be used in the future to train rats in this paradigm. Time course experiments indicate decreasing discriminative performance from 20-240 min postadministration with a calculated half-life of 162.3 min. Administration of 450, 600, and 900 mg/kg ethanol (10% w/v) I.P. produced saline-like discriminative responding, whereas the combinat...Continue Reading

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Citations

Feb 23, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Nararak LeesakulChittanon Buranachai

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