Role and action in the pituitary corticotroph of corticotropin-releasing factor (CRF) in the hypothalamus

Peptides
Kazunori Kageyama, Toshihiro Suda

Abstract

Corticotropin-releasing factor (CRF), produced in the hypothalamic paraventricular nucleus (PVN) in response to stress, stimulates the synthesis and secretion of adrenocorticotropin (ACTH) via CRF receptor type 1 (CRF(1) receptor) in the anterior pituitary (AP) of mammals. CRF is critical for the circadian rhythmicity of the hypothalamic-pituitary-adrenal axis and the augmented release of ACTH from the pituitary in response to the stress. A higher molecular weight form of immunoreactive beta-endorphin, putative proopiomelanocortin (POMC), is increased in CRF-knockout mice (CRF KO), suggesting the important role of CRF in the processing of POMC. In fact, CRF is able to modulate the processing of POMC through changes in prohormone convertase (PC)-1 expression levels. Multiple forms of ACTH-related peptides containing unprocessed ones are present in some cases of ACTH-producing tumors, presumably without action of PC-1 under the control of CRF. Following CRF-activated stimulation of the receptor signaling, CRF(1) receptor is down-regulated and desensitized. In fact, CRF facilitates the degradation of CRF(1) receptor mRNA via the protein kinase A pathway. Prolonged agonist activation of CRF(1) receptor leads to a loss of responsive...Continue Reading

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S BenjannetN G Seidah
Aug 1, 1989·Molecular and Cellular Endocrinology·M G CastroY P Loh
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·T SudaT Sumitomo
Feb 8, 2000·The Journal of Biological Chemistry·B C BlaxallJ D Port
May 19, 2000·Annals of the New York Academy of Sciences·M H Perrin, W W Vale
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F M DautzenbergR L Hauger
Jul 14, 2001·Frontiers of Hormone Research·E W Hillhouse, D K Grammatopoulos
Apr 6, 2002·Archives of Physiology and Biochemistry·M NikodemovaG Aguilera
May 28, 2002·Molecular and Cellular Biochemistry·Burns C BlaxallJ David Port
Nov 5, 2002·Biochemical and Biophysical Research Communications·Frank M DautzenbergRichard L Hauger
Dec 19, 2002·Molecular Pharmacology·Trudy A Kohout, Robert J Lefkowitz
May 8, 2003·The Journal of Pharmacology and Experimental Therapeutics·Richard L HaugerFrank M Dautzenberg
May 12, 2004·Peptides·Greti AguileraKevin J Catt
Oct 23, 2008·Regulatory Peptides·Kazunori KageyamaToshihiro Suda

❮ Previous
Next ❯

Citations

Feb 10, 2010·Zoological Science·Tsuyoshi KawadaHonoo Satake
Dec 20, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Anna FeldreichAnnika Rosén
May 11, 2017·Frontiers in Neuroscience·Andreas Stengel, Yvette F Taché

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.