Abstract
We previously found that hepatic stellate cell activation induced by autophagy maintains the liver architecture to prevent collapse during acute liver failure. Nitric oxide has shown to induce hepatic stellate cell apoptosis. Whether and how nitric oxide is involved in acute liver failure and autophagy remains unclear. Acute liver failure patients were recruited to investigate the correlation between plasma nitric oxide levels and clinical features. Liver tissues were collected from chronic hepatitis patients by biopsy and from acute liver failure patients who had undergone liver transplantation. The expression of nitric oxide synthases and hepatic stellate cell activation (alpha-SMA), and autophagic activity (LC3) were investigated by immunohistochemistry. Autophagy and apoptosis were investigated by immunoblot analysis, confocal microscopy, and flow cytometry in hepatic stellate cells treated with nitric oxide donors. Plasma nitric oxide level was significantly increased in patients with acute liver failure compared to those with cirrhosis (53.60±19.74 μM vs 19.40±9.03 μM, Z=-7.384, P<.001) and positively correlated with MELD-Na score (r=.539, P<.001), implicating nitric oxide in acute liver failure. At least some Nitric oxid...Continue Reading
References
Jun 4, 1999·Journal of Gastroenterology and Hepatology·B N TandonS K Acharya
Feb 22, 2001·The Journal of Clinical Investigation·G SassG Tiegs
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Razao IssaJohn Iredale
Aug 5, 2003·The Journal of Pathology·Nasser A MohammedRaymond F T McMahon
Oct 14, 2004·Gastroenterology·Xuemin WangZixu Mao
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie PolsonUNKNOWN American Association for the Study of Liver Disease
Apr 3, 2008·European Journal of Clinical Investigation·O LukivskayaV U Buko
May 7, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel A LangerVijay H Shah
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Zeguang WuQin Ning
Feb 22, 2011·Acta Biochimica Et Biophysica Sinica·Kuntang ShenXinyu Qin
Jul 6, 2011·Molecular Cell·Sovan SarkarDavid C Rubinsztein
Oct 18, 2011·Clinical and Experimental Medicine·Tianyan ChenYingren Zhao
Nov 16, 2011·Autophagy·Lien F R ThoenLeo A van Grunsven
Jan 14, 2012·Gastroenterology·Virginia Hernández-GeaScott L Friedman
Sep 29, 2012·The Journal of Pathology·Domenico Del PrincipeAnna Maria Giammarioli
Apr 30, 2014·BioMed Research International·Yang SongChangqing Yang
Jun 7, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Mahnoush S ShafieiDon C Rockey
Jun 22, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hao HeTakashi Ikejima
Aug 8, 2014·PloS One·Ruiping ZhouZhi-Ying Chen
Nov 5, 2014·Antioxidants & Redox Signaling·Adelheid WeidingerAndrey V Kozlov
Nov 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Yingli HeYingren Zhao
May 1, 2015·Cell Cycle·Kewei Wang
May 24, 2015·Acta Diabetologica·YingLi HeYingRen Zhao
Jun 11, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Taotao YanYingren Zhao
Jul 16, 2015·Scandinavian Journal of Immunology·L JinY He
Citations
Oct 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Svenja Sydor, Lars P Bechmann
Apr 13, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhen TianYingli He
Jan 19, 2019·Cancer Science·XiaoGang ZhangYingLi He
Jul 2, 2019·Experimental and Therapeutic Medicine·Xiuqing LiYoushan Wu
Jun 1, 2018·Canadian Journal of Gastroenterology & Hepatology·YiMin ZhangLanJuan Li
Jan 29, 2020·Biotechnology Letters·Sujuan ChenHaijie Yang
Jul 14, 2018·Acta Pharmacologica Sinica·Shi-Gang QiaoHui-Ling Zhang
Aug 21, 2020·Redox Biology·Wojciech OrnatowskiStephen M Black
Nov 5, 2019·Biochimica Et Biophysica Acta. General Subjects·Mohd Javed AkhtarSalman A Alrokayan
Nov 25, 2020·Cell Metabolism·Parth TrivediScott L Friedman
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Dec 19, 2020·Journal of Extracellular Vesicles·Gensheng ZhangZhijian Cai
Mar 30, 2021·Clinical and Experimental Hypertension : CHE·Di LiuGuo-Xing Zhang
Apr 4, 2021·Antioxidants·Iulia Olimpia PfingstgrafAlina Elena Pârvu
Jul 7, 2021·Expert Review of Gastroenterology & Hepatology·Shiyun PuHoufeng Zhou