Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure

Liver International : Official Journal of the International Association for the Study of the Liver
Li JinYingli He

Abstract

We previously found that hepatic stellate cell activation induced by autophagy maintains the liver architecture to prevent collapse during acute liver failure. Nitric oxide has shown to induce hepatic stellate cell apoptosis. Whether and how nitric oxide is involved in acute liver failure and autophagy remains unclear. Acute liver failure patients were recruited to investigate the correlation between plasma nitric oxide levels and clinical features. Liver tissues were collected from chronic hepatitis patients by biopsy and from acute liver failure patients who had undergone liver transplantation. The expression of nitric oxide synthases and hepatic stellate cell activation (alpha-SMA), and autophagic activity (LC3) were investigated by immunohistochemistry. Autophagy and apoptosis were investigated by immunoblot analysis, confocal microscopy, and flow cytometry in hepatic stellate cells treated with nitric oxide donors. Plasma nitric oxide level was significantly increased in patients with acute liver failure compared to those with cirrhosis (53.60±19.74 μM vs 19.40±9.03 μM, Z=-7.384, P<.001) and positively correlated with MELD-Na score (r=.539, P<.001), implicating nitric oxide in acute liver failure. At least some Nitric oxid...Continue Reading

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Citations

Oct 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Svenja Sydor, Lars P Bechmann
Apr 13, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhen TianYingli He
Nov 25, 2020·Cell Metabolism·Parth TrivediScott L Friedman
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Dec 19, 2020·Journal of Extracellular Vesicles·Gensheng ZhangZhijian Cai
Mar 30, 2021·Clinical and Experimental Hypertension : CHE·Di LiuGuo-Xing Zhang
Jul 7, 2021·Expert Review of Gastroenterology & Hepatology·Shiyun PuHoufeng Zhou

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