Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens

Scientific Reports
Shu-Cheng HuangJia-Kui Li

Abstract

Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it is intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that bone is a highly vascularized tissue dependent on the coordinated coupling between angiogenesis and osteogenesis, but the underlying mechanisms of bone formation and bone remodeling are poorly defined in TD chickens. Here, we observed that inhibition of vasculogenesis and angiogenesis remarkably impaired vascular invasion in the hypertrophic chondrocyte zone of the TGPs, resulting in the massive death of chondrocytes due to a shortage of blood vessels and nutrients. Moreover, the balance of the OPG (osteoprotegerin)/RANKL (receptor activator of nuclear factor-kB ligand) system is also severely disrupted during the osteogenesis process while coupling with angiogenesis, both of which eventually lead to abnormal endochondral bone formation in TD chickens. Thus, the process of vascular formation in endochondral bone appears to initiate the pathological changes in TD, and improvement of this process during coupling with osteogenesis may be a potential therapeutic approach to treat this intractable...Continue Reading

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Citations

Aug 23, 2019·Poultry Science·Shucheng HuangXuebing Wang
Jan 22, 2020·Environmental Science and Pollution Research International·Xiong JiangJiakui Li
Jul 2, 2021·Frontiers in Physiology·Rubin FanZhenlei Zhou
Nov 11, 2021·Probiotics and Antimicrobial Proteins·Tingting XuShucheng Huang

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Methods Mentioned

BETA
ELISA
ELISAs
electrophoresis
dissection
PCR
X-ray

Software Mentioned

GraphPad
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