Role and regulation of the stress activated sigma factor sigma B (σB ) in the saprophytic and host-associated life stages of Listeria monocytogenes

Advances in Applied Microbiology
Amber DoreyConor O'Byrne

Abstract

The stress activated sigma factor sigma B (σB) plays a pivotal role in allowing the food-borne bacterial pathogen Listeria monocytogenes to modulate its transcriptional landscape in order to survive in a variety of harsh environments both outside and within the host. While we have a comparatively good understanding of the systems under the control of this sigma factor much less is known about how the activity of σB is controlled. In this review, we present a current model describing how this sigma factor is thought to be controlled including an overview of what is known about stress sensing and the early signal transduction events that trigger its activation. We discuss the known regulatory overlaps between σB and other protein and RNA regulators in the cell. Finally, we describe the role of σB in surviving both saprophytic and host-associated stresses. The complexity of the regulation of this sigma factor reflects the significant role that it plays in the persistence of this important pathogen in the natural environment, the food chain as well as within the host during the early stages of an infection. Understanding its regulation will be a critical step in helping to develop rational strategies to prevent its growth and survi...Continue Reading

Citations

Mar 4, 2020·FEMS Microbiology Letters·Catarina M MarinhoPascal Piveteau
Sep 6, 2019·Microbiology and Molecular Biology Reviews : MMBR·Ahmed GaballaKathryn J Boor
Jul 14, 2020·FEMS Microbiology Letters·Paramaporn RattanaphanNatta Tansila
Jul 3, 2020·Frontiers in Molecular Biosciences·Juan José González Plaza
Feb 2, 2021·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel
Apr 4, 2021·Applied and Environmental Microbiology·Charlotte DessauxFrancisco García-Del Portillo

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