Role and significance of plasma citrulline in the early phase after small bowel transplantation in pigs

Transplant International : Official Journal of the European Society for Organ Transplantation
Silvio NadalinMassimo Malagó

Abstract

A reliable serological marker of acute cellular rejection (ACR) after small bowel transplantation (SBTx) is still missing. Plasma citrulline level (PCL) reflects the functional integrity of intestinal mucosa which is partially lost during ACR. The aim of our study was to investigate the role of PCL as marker of ACR after SBTx. Eighteen German landrace pigs were used and divided into three groups. Group 1 (G1), autologous SBTx (n = 4) as control; group 2 (G2), allogeneic SBTx without immunosuppression (IS) (n = 7) and group 3 (G3), allogeneic SBTx with IS (n = 7). IS consisted of tacrolimus and steroids without induction treatment. Observation period was 14 days. Mucosal biopsies were obtained intraoperatively and daily using a Thiry-Vella loop. ACR was differentiated into indeterminate, mild, moderate and severe using a standardized grading schema. PCL was measured daily. An ACR onset occurred generally from postoperative day 4 both in G2 and G3 as mild form and developed differently in the two groups: moderate to severe in G2 and indeterminate to mild in G3. A significant decline of PCL occurred only in cases of moderate and severe ACR, but not in cases of indeterminate and mild ACR. The PCL failed as a marker in the early dia...Continue Reading

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Citations

Feb 23, 2010·Transplantation Proceedings·P RuizA G Tzakis
Dec 1, 2009·Journal of Pediatric Surgery·Yun ChenShu-Hsun Chu
Sep 25, 2009·The Journal of Surgical Research·Ming-Shian TsaiWei-Jao Chen
Oct 4, 2011·The Journal of Surgical Research·Sandra WeihArianeb Mehrabi
Apr 29, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pascal CrennLuc Cynober
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Emmanuel CurisLuc Cynober

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