Jan 20, 1989

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity

P K SonsallaR E Heikkila


The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to experimental animals produces degenerative changes in nigrostriatal dopaminergic neurons or their axon terminals. This study was conducted to determine if excitatory amino acids, which appear to be involved in various neurodegenerative disorders, might also contribute to the dopaminergic neurotoxicity produced in mice by either methamphetamine or MPTP. MK-801, phencyclidine, and ketamine, noncompetitive antagonists of one subtype of excitatory amino acid receptor, the N-methyl-D-aspartate receptor, provided substantial protection against neurotoxicity produced by methamphetamine but not that produced by MPTP. These findings indicate that excitatory amino acids play an important role in the nigrostriatal dopaminergic damage induced by methamphetamine.

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Mentioned in this Paper

Presynaptic Terminals
Excitatory Amino Acid Receptor
Abnormal Degeneration
Myopia, Degenerative
Phencyclidine Hydrobromide
Amino Acids, I.V. solution additive
Neurodegenerative Disorders Pathway
Lentiform Nucleus Structure

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