Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers

International Journal of Molecular Sciences
Meng ChengRamakrishna Kommagani

Abstract

Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance. Thus, we need to define the downstream effectors of sex hormones in order to develop new treatment strategies for these cancers. Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). GREB1 is an early estrogen-responsive gene, and its expression is correlated with estrogen levels in breast cancer patients. Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells. Recent studies have shown that GREB1 also responds to progesterone in human endometrial cells, suggesting that GREB1 is a pan steroid-responsive gene. This mini-review examines evidence that GREB1 participates in several hormone-dependent cancers and could be targeted to treat these cancers.

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Citations

Dec 18, 2019·Histopathology·Amir Momeni-Boroujeni, Sarah Chiang
Jun 19, 2020·Healthcare·Antonio Sanchez-FernandezMaría Pedrera-Canal
Feb 9, 2021·Frontiers in Endocrinology·Codruţa ŞoicaAlexandra Mioc
Mar 27, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Britt DuijndamBob van de Water
May 26, 2021·Molecular and Cellular Endocrinology·Melissa C McHannJosée Guindon

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Methods Mentioned

BETA
X-ray
glycosylation
immunoprecipitation
xenograft

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