Role for RpoS but not RelA of Legionella pneumophila in modulation of phagosome biogenesis and adaptation to the phagosomal microenvironment.

Infection and Immunity
Alaeddin Abu-ZantYousef Abu Kwaik

Abstract

The induction of virulence traits by Legionella pneumophila at the post-exponential phase has been proposed to be triggered by the stringent response mediated by RelA, which triggers RpoS. We show that L. pneumophila rpoS but not relA is required for early intracellular survival and replication within human monocyte-derived macrophages and Acanthamoeba polyphaga. In addition, L. pneumophila rpoS but not relA is required for expression of the pore-forming activity. We provide evidence that RpoS plays a role in the modulation of phagosome biogenesis and in adaptation to the phagosomal microenvironment. Thus, there is no functional link between the stringent response and RpoS in the pathogenesis of L. pneumophila.

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Citations

Dec 2, 2009·Infection and Immunity·Tao Dong, Herb E Schellhorn
Feb 17, 2009·Journal of Bacteriology·Galadriel Hovel-MinerSergey Kalachikov
May 29, 2010·Microbiology and Molecular Biology Reviews : MMBR·Zachary D DalebrouxMichele S Swanson
May 1, 2007·International Journal of Medical Microbiology : IJMM·Michael SteinertGernot Glöckner
Dec 2, 2008·Molecular Microbiology·Zachary D DalebrouxMichele S Swanson
Oct 1, 2010·Environmental Microbiology Reports·Souhaila Al-KhodorYousef Abu Kwaik
Mar 12, 2015·Microbiology·Ana VieiraAndrey V Karlyshev
Mar 29, 2013·Virulence·Ashley M RichardsYousef Abu Kwaik
Jan 8, 2015·Frontiers in Microbiology·Peter RobertsonRafael A Garduño
Nov 12, 2013·FEMS Microbiology Letters·Hany Abdelhady, Rafael A Garduño
Jan 14, 2012·PLoS Pathogens·Pavel DolezalTrevor Lithgow
Mar 5, 2016·Molecular Microbiology·Jennifer R TannerAnn Karen C Brassinga
Nov 25, 2014·Applied and Environmental Microbiology·Hana TriguiSebastien P Faucher
May 1, 2019·Antimicrobial Agents and Chemotherapy·Ingrid C McCallBruce R Levin
Jan 31, 2020·Frontiers in Cellular and Infection Microbiology·Alejandro ZúñigaVerónica Cambiazo
May 22, 2021·Molecular Microbiology·Christopher I GrahamAnn Karen C Brassinga

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