Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers

European Journal of Clinical Pharmacology
Osamu AbeS Misaka

Abstract

The aim of the present study is to investigate a possible role of a single dose of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, for the pharmacokinetic interaction between green tea and nadolol in humans. In a randomized three-phase crossover study, 13 healthy volunteers received single doses of 30 mg nadolol orally with water (control), or an aqueous solution of EGCG-concentrated green tea extract (GTE) at low or high dose. Plasma concentrations and urinary excretion of nadolol were determined up to 48 h. In addition, blood pressure and pulse rate were monitored. In vitro transport kinetic experiments were performed using human embryonic kidney 293 cells stably expressing organic anion transporting polypeptide (OATP)1A2 to evaluate the inhibitory effect of EGCG on OATP1A2-mediated substrate transport. Single coadministration of low and high dose GTE significantly reduced the plasma concentrations of nadolol. The geometric mean ratios with 90% CI for area under the plasma concentration-time curves from 0 to infinity of nadolol were 0.72 (0.56-0.87) for the low and 0.60 (0.51-0.69) for the high dose. There were no significant differences in Tmax, elimination half-life, and renal clearance between GTE and...Continue Reading

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Citations

May 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changwei LiuSheng Zhang
Jan 10, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuta FunaiKatsuhisa Inoue
Sep 27, 2019·Current Developments in Nutrition·Rattiyaporn Kanlaya, Visith Thongboonkerd
Apr 17, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Shingen Misaka, Kenju Shimomura
Apr 23, 2020·British Journal of Clinical Pharmacology·Shingen MisakaKenju Shimomura
Jan 8, 2020·BMC Pharmacology & Toxicology·Cecilia Nwadiuto Amadi, Wisdom Izuchukwu Nwachukwu
Jan 31, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Khaled S AbdelkawyNoha M El-Khodary
Sep 5, 2019·Chemistry & Biodiversity·Yanping ZhouGuiqing Jia
Oct 14, 2020·Clinical and Translational Science·Shingen MisakaKenju Shimomura
Jan 3, 2021·Journal of Clinical Pharmacology·Sho ShimazakiShingen Misaka
Jul 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong-Jie TanSiew-Keah Lee
Nov 20, 2020·Journal of Agricultural and Food Chemistry·Tokio MoritaHisakazu Ohtani

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Methods Mentioned

BETA
Protein Assay
genotyping

Software Mentioned

Dixon
Prism
Sigma Plot
Plot

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