PMID: 3320570Jan 1, 1987Paper

Role of 18-hydroxylated cortisols in hypertension

Journal of Steroid Biochemistry
C E Gomez-SanchezO B Holland

Abstract

The isolation of 18-hydroxycortisol and 18-oxocortisol was recently described. These steroids have been shown to be excreted in exaggerated quantities in patients with primary aldosteronism, with adrenal adenomas and in glucocorticoid suppressible aldosteronism. We report the measurement of both steroids in the urine of patients with essential hypertension. 18-Oxocortisol excretion did not differ in patients with normal renin essential hypertension (0.7 +/- 0.7 micrograms/24 h), low renin essential hypertension (0.7 +/- 0.5 micrograms/24 h) and normal individuals (1.2 +/- 0.9 micrograms/24 h). Patients with normal renin hypertension excreted 54 +/- 43 micrograms/24 h of 18-hydroxycortisol, those with low renin essential hypertension excreted 58 +/- 54 micrograms/24 h, and normal individuals excreted 63 +/- 36 micrograms/24 h. Three of the low renin and one of the normal renin hypertensive subjects excreted greater quantities of 18-hydroxycortisol than the upper limit of normal, but all excreted normal quantities of 18-oxocortisol. As 18-hydroxycortisol is inactive, the meaning of this elevated excretion is unclear, but it may be a marker of an adrenal enzymatic abnormality which may be playing a more direct role in hypertension.

References

Jul 1, 1976·The Journal of Clinical Investigation·G H WilliamsR H Underwood
Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R J AgrinJ C Melby
Jun 1, 1976·Annals of Internal Medicine·N M KaplanC Gomez-Sanchez
May 1, 1975·Journal of Steroid Biochemistry·J C Melby, S L Dale
Jan 1, 1985·Endocrinology·C E Gomez-SanchezM F Foecking
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·C E Gomez-SanchezA Ganguly
Jan 1, 1987·Journal of Steroid Biochemistry·C E Gomez-SanchezE P Gomez-Sanchez
Feb 1, 1985·The Journal of Clinical Endocrinology and Metabolism·C E Gomez-SanchezR Upcavage
Mar 1, 1986·Hypertension·C E Gomez-Sanchez
Apr 1, 1986·Hypertension·C E Hall, C E Gomez-Sanchez
Aug 1, 1984·Endocrinology·E P Gomez-SanchezM Foecking
Jan 1, 1984·Endocrine Research·C E Gomez-Sanchez
Mar 15, 1982·Biochemical Pharmacology·C E Gomez-Sanchez
Apr 1, 1983·Molecular and Cellular Endocrinology·J F Crivello, G N Gill
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·C E Gomez-SanchezM H Weinberger
Dec 1, 1983·Endocrinology·S UlickM D Chu
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·S Ulick, M D Chu
Sep 8, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·M SchöneshöferH J Dulce
Feb 1, 1981·The Journal of Clinical Endocrinology and Metabolism·C E Gomez-Sanchez, O B Holland

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Citations

Apr 6, 2004·Molecular and Cellular Endocrinology·Jérôme NicodPaolo Ferrari
Mar 28, 2007·American Journal of Hypertension·Paola KrallCarlos Fardella
Sep 15, 2017·European Journal of Endocrinology·Jacques W M LendersCelso E Gomez-Sanchez
Feb 7, 1998·Hypertension·H M KubischE P Gómez-Sánchez
Jan 1, 1992·Journal of Endocrinological Investigation·I MiyamoriR Takeda
Nov 14, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Stefania Morra di CellaCelso E Gomez-Sanchez

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